Publication Name	World Journal of Experimental Medicine
Manuscript ID	20017
Country	Greece

Received	2015-05-27 20:39
Peer-Review Started	2015-05-30 11:42
To Make the First Decision	2015-07-03 16:46
Return for Revision	2015-07-10 19:06
Revised	2015-07-21 02:00
Second Decision	2015-09-02 10:31
Accepted by Journal Editor-in-Chief	2015-09-02 18:04
Accepted by Executive Editor-in-Chief	2015-09-16 18:39
Articles in Press	2015-09-16 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-13 18:34
Publish the Manuscript Online	2015-11-23 08:36

ISSN	2220-315x (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Editorial
Article Title	Polycystins and mechanotransduction: From physiology to disease
Manuscript Source	Invited Manuscript
All Author List	Christina Piperi and Efthimia K Basdra
Funding Agency and Grant Number
Corresponding Author	Efthimia K Basdra, Associate Professor, Department of Biological Chemistry - Cellular and Molecular Biomechanics Unit, Medical School, University of Athens Medical School, 75, M. Asias Street, 11527 Athens, Greece. ebasdra@med.uoa.gr
Key Words	Polycystins; Mechanotransduction; Kidney; Endothelium; Osteoblasts; Cancer
Core Tip	Polycystins are key regulators of mechano-sensation in several cell types including kidney, vascular endothelial and smooth muscle cells, osteoblasts and cardiac myocytes. Their expression in primary cilium, plasma membrane and endoplasmic reticulum, along with their ability to interact with diverse ion channels, cell-cell and cell-extracellular matrix junctional proteins renders polycystins as essential regulators of overall cellular mechanoresponse. Abnormal expression or genetic defects of polycystins result in severe structural and mechanosensing faults including cyst formation, deregulated flow sensing, aneurysms, defective bone development and cancer progression, highlighting their crucial role in human physiology.
Publish Date	2015-11-23 08:36
Citation	Piperi C, Basdra EK. Polycystins and mechanotransduction: From physiology to disease. World J Exp Med 2015; 5(4): 200-205
URL	http://www.wjgnet.com/2220-315X/full/v5/i4/200.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i4.200

Full Article (PDF)	WJEM-5-200.pdf
Full Article (Word)	WJEM-5-200.doc
Manuscript File	20017-Review.doc
Answering Reviewers	20017-Answering reviewers.pdf
Audio Core Tip	20017-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20017-Conflict-of-interest statement.pdf
Copyright License Agreement	20017-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20017-Language certificate.pdf
Peer-review Report	20017-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20017-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20017-Scientific misconduct check.pdf
Scientific Editor Work List	20017-Scientific editor work list.pdf