Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	20045
Country	United States

Received	2015-05-28 09:30
Peer-Review Started	2015-06-01 11:59
To Make the First Decision	2015-08-14 15:27
Return for Revision	2015-08-22 15:57
Revised
Second Decision	2015-09-30 19:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-19 15:10
Articles in Press	2015-10-19 15:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-20 21:15
Publish the Manuscript Online	2015-11-10 12:29

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Field of Vision
Article Title	Pediatric obesity prevention: From naïve examination of energy imbalance towards strategies that influence the competition for nutrient resources among tissues
Manuscript Source	Invited Manuscript
All Author List	Lynae J Hanks, Tina Simpson, Kenneth McCormick and Krista Casazza
Funding Agency and Grant Number
Corresponding Author	Krista Casazza, PhD, RD, LD, Associate Professor, Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Alabama at Birmingham,1601 5th Ave S, CPPI 310, Birmingham, AL 35223, United States. kcasazza@peds.uab.edu
Key Words	Childhood obesity; Metabolic control; Energy balance; Resistance training; Effective intervention strategies; Weight loss; Musculoskeletal health
Core Tip	As obesity-related recommendations stand today, most are unproven and ineffective. While energy balance is an integral component, the etiology of pediatric obesity is a consequence of adipocytes “out competing” other cell types (e.g., myocytes, osteocytes, hepatocytes) for energy. The cumulative effect of fat storage, energetically less costly is at the expense of optimal development of other tissues. The out-competition, due to hyperplasia and hypertrophy of adipocytes impairs physiologic pathways producing metabolically compromised obese children irreversible with “simple” energy balance paradigms. Via the activation of endocrine and paracrine effects of the musculoskeletal system, resistance training may be an effective strategy to improve health independent of initial weight loss. However, forced stress on the system is requisite (e.g., resistance training). Resistance training induces systemic anabolism and enhances nutrient delivery and utilization, which are integral in optimizing metabolic control and body composition during growth and development, and in turn overall lifelong health.
Publish Date	2015-11-10 12:29
Citation	Hanks LJ, Simpson T, McCormick K, Casazza K. Pediatric obesity prevention: From naïve examination of energy imbalance towards strategies that influence the competition for nutrient resources among tissues. World J Clin Pediatr 2015; 4(4): 50-54
URL	http://www.wjgnet.com/2219-2808/full/v4/i4/50.htm
DOI	http://dx.doi.org/10.5409/wjcp.v4.i4.50

Full Article (PDF)	WJCP-4-50.pdf
Full Article (Word)	WJCP-4-50.doc
Manuscript File	20045-Review.docx
Answering Reviewers	20045-Answering reviewers.pdf
Audio Core Tip	20045-Audio core tip.m4a
Biostatistics Review Certificate	Biostatistics_Statement_20150528004209.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20150528004337.pdf
Conflict-of-Interest Disclosure Form	20045-Conflict-of-interest statement.pdf
Copyright License Agreement	20045-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150528004238.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20150528004509.pdf
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20150528004149.pdf
Peer-review Report	20045-Peer-review(s).pdf
Scientific Misconduct Check	20045-Scientific misconduct check.pdf
Scientific Editor Work List	20045-Scientific editor work list.pdf