Publication Name	World Journal of Respirology
Manuscript ID	20109
Country	Singapore

Received	2015-05-28 16:58
Peer-Review Started	2015-05-28 22:24
First Decision by Editorial Office Director
Return for Revision	2015-08-04 11:22
Revised	2015-08-27 15:50
Publication Fee Transferred
Second Decision by Editor	2015-09-21 17:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-10-08 18:14
Articles in Press	2015-10-08 18:14
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-11 16:11
Publish the Manuscript Online	2015-11-30 09:06

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Respiratory System
Manuscript Type	Minireviews
Article Title	β2-adrenoceptor in obstructive airway diseases: Agonism, antagonism or both?
Manuscript Source	Invited Manuscript
All Author List	Daniel WS Tan, Jyi Lin Wong, Siew Teck Tie, John A Abisheganaden, Albert YH Lim and WS Fred Wong
Funding Agency and Grant Number	Funding Agency Grant Number National Medical Research Council of Singapore NMRC/CBRG/0027/2012(In part) NUHS Seed Fund R-184-000-238-112
Corresponding Author	Dr. WS Fred Wong, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 16 Medical Drive, MD3 #04-01, Singapore 117600, Singapore. phcwongf@nus.edu.sg
Key Words	β-adrenoceptors; β2-agonist; β-blocker; Inverse agonist; Heart failure; β-arrestin
Core Tip	This review summarizes the effect and usage of β2-agonist in obstructive airway disease, addressing the benefits and potential risks of β2-agonist. The review also looks at the safety of β-blocker for cardiovascular disease in patients with obstructive airway disease. There is also emerging evidence that non-selective β-blockers with inverse agonism ironically can have long-term beneficial effects in obstructive airway disease beyond cardiovascular protection. Further trials are urgently needed in this field as it might lead to a dramatic turnaround in clinical practice for obstructive airway diseases as has already been seen in the usage of β-blockers for heart failure.
Publish Date	2015-11-30 09:06
Citation	Tan DWS, Wong JL, Tie ST, Abisheganaden JA, Lim AYH, Wong WSF. β2-adrenoceptor in obstructive airway diseases: Agonism, antagonism or both? World J Respirol 2014; 5(3): 199-206
URL	http://www.wjgnet.com/2218-6255/full/v5/i3/199.htm
DOI	http://dx.doi.org/10.5320/wjr.v5.i3.199

Full Article (PDF)	WJR-5-199.pdf
Full Article (Word)	WJR-5-199.doc
Manuscript File	20109-Review.docx
Answering Reviewers	20109-Answering reviewers.pdf
Audio Core Tip	20109-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20109-Conflict-of-interest statement.pdf
Copyright License Agreement	20109-Copyright assignment.pdf
Peer-review Report	20109-Peer-review(s).pdf
Scientific Misconduct Check	20109-Scientific misconduct check.pdf
Scientific Editor Work List	20109-Scientific editor work list.pdf