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11/30/2015 9:07:00 AM | Browse: 447 | Download: 692
Publication Name World Journal of Respirology
Manuscript ID 20109
Country/Territory Singapore
2015-05-28 16:58
Peer-Review Started
2015-05-28 22:24
To Make the First Decision
2015-07-27 15:49
Return for Revision
2015-08-04 11:22
2015-08-27 15:50
Second Decision
2015-09-21 17:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-10-08 18:14
Articles in Press
2015-10-08 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-11 16:11
Publish the Manuscript Online
2015-11-30 09:06
ISSN 2218-6255 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Respiratory System
Manuscript Type Minireviews
Article Title β2-adrenoceptor in obstructive airway diseases: Agonism, antagonism or both?
Manuscript Source Invited Manuscript
All Author List Daniel WS Tan, Jyi Lin Wong, Siew Teck Tie, John A Abisheganaden, Albert YH Lim and WS Fred Wong
Funding Agency and Grant Number
Funding Agency Grant Number
National Medical Research Council of Singapore NMRC/CBRG/0027/2012(In part)
NUHS Seed Fund R-184-000-238-112
Corresponding author Dr. WS Fred Wong, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 16 Medical Drive, MD3 #04-01, Singapore 117600, Singapore. phcwongf@nus.edu.sg
Keywords β-adrenoceptors; β2-agonist; β-blocker; Inverse agonist; Heart failure; β-arrestin
Core Tip This review summarizes the effect and usage of β2-agonist in obstructive airway disease, addressing the benefits and potential risks of β2-agonist. The review also looks at the safety of β-blocker for cardiovascular disease in patients with obstructive airway disease. There is also emerging evidence that non-selective β-blockers with inverse agonism ironically can have long-term beneficial effects in obstructive airway disease beyond cardiovascular protection. Further trials are urgently needed in this field as it might lead to a dramatic turnaround in clinical practice for obstructive airway diseases as has already been seen in the usage of β-blockers for heart failure.
Publish Date 2015-11-30 09:06
Citation Tan DWS, Wong JL, Tie ST, Abisheganaden JA, Lim AYH, Wong WSF. β2-adrenoceptor in obstructive airway diseases: Agonism, antagonism or both? World J Respirol 2014; 5(3): 199-206
Url http://www.wjgnet.com/2218-6255/full/v5/i3/199.htm
DOI http://dx.doi.org/10.5320/wjr.v5.i3.199
Full Article (PDF) WJR-5-199.pdf
Full Article (Word) WJR-5-199.doc
Manuscript File 20109-Review.docx
Answering Reviewers 20109-Answering reviewers.pdf
Audio Core Tip 20109-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20109-Conflict-of-interest statement.pdf
Copyright License Agreement 20109-Copyright assignment.pdf
Peer-review Report 20109-Peer-review(s).pdf
Scientific Misconduct Check 20109-Scientific misconduct check.pdf
Scientific Editor Work List 20109-Scientific editor work list.pdf