Publication Name	World Journal of Gastroenterology
Manuscript ID	20133
Country	Italy

Received	2015-05-29 10:20
Peer-Review Started	2015-06-01 08:34
To Make the First Decision	2015-07-14 11:48
Return for Revision	2015-07-24 16:47
Revised	2015-08-06 22:01
Second Decision	2015-10-10 18:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-13 18:27
Articles in Press	2015-10-13 18:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-05 17:54
Publish the Manuscript Online	2016-01-20 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Caecilia HC Sukowati, Korri E El-Khobar, Susan I Ie, Beatrice Anfuso, David H Muljono and Claudio Tiribelli
Funding Agency and Grant Number
Corresponding Author	Caecilia HC Sukowati, PhD, Fondazione Italiana Fegato ONLUS, AREA Science Park Basovizza, SS14 km 163.5, 34149 Trieste, Italy. caecilia.sukowati@csf.units.it
Key Words	Hepatocellular carcinoma; Hepatitis B virus; Hepatitis C virus; Oncogenicity; Viral pathogenicity
Core Tip	According to the most recent data released by the International Agency for Research on Cancer-World Health Organization, liver cancer is the second most common cause of cancer mortality worldwide. Hepatocellular carcinoma (HCC) accounts for around 90% of liver cancer cases and it is variably distributed according to its main risk factors. The hepatotropic viral [hepatitis B virus (HBV) and hepatitis C virus (HCV)] infection can cause a disarrangement in cellular pathways through an indirect and/or direct mechanism in liver injury. This review summarize available data in literature regarding the oncogenic properties of HBV and HCV in the initiation of HCC, including their role in the activation of hepatic stem cells.
Publish Date	2016-01-20 16:55
Citation	Sukowati CHC, El-Khobar KE, Ie SI, Anfuso B, Muljono DH, Tiribelli C. Significance of hepatitis virus infection in the oncogenic initiation of hepatocellular carcinoma. World J Gastroenterol 2016; 22(4): 1497-1512
URL	http://www.wjgnet.com/1007-9327/full/v22/i4/1497.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i4.1497

Full Article (PDF)	WJG-22-1497.pdf
Full Article (Word)	WJG-22-1497.doc
Manuscript File	20133-Review.docx
Answering Reviewers	20133-Answering reviewers.pdf
Audio Core Tip	20133-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	20133-Conflict-of-interest statement.pdf
Copyright License Agreement	20133-Copyright assignment.pdf
Peer-review Report	20133-Peer-review(s).pdf
Scientific Misconduct Check	20133-Scientific misconduct check.pdf
Scientific Editor Work List	20133-Scientific editor work list.pdf