Publication Name	World Journal of Gastroenterology
Manuscript ID	20143
Country	Italy

Received	2015-05-29 10:00
Peer-Review Started	2015-06-01 09:55
First Decision by Editorial Office Director
Return for Revision	2015-10-15 14:04
Revised	2015-12-05 19:35
Publication Fee Transferred
Second Decision by Editor	2015-12-18 16:04
Second Decision by Editor-in-Chief	2015-12-18 17:01
Final Decision by Editorial Office Director	2015-12-30 17:41
Articles in Press	2015-12-30 17:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-23 11:36
Publish the Manuscript Online	2016-01-31 11:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Eleonora Distrutti, Lorenzo Monaldi, Patrizia Ricci and Stefano Fiorucci
Funding Agency and Grant Number
Corresponding Author	Eleonora Distrutti, MD, S.C. di Gastroenterologia ed Epatologia, Azienda Ospedaliera di Perugia, 06100 Perugia, Italy. eleonoradistrutti@katamail.com
Key Words	Irritable bowel syndrome; Gut microbiota; Probiotics; Prebiotics; Synbiotics; Antibiotics; Fecal transplantation
Core Tip	In the last decade, the gut microbiota has provided support to the concept that a disturbed intestinal ecology could promote development and maintenance of symptoms in irritable bowel syndrome (IBS). As a correlate, manipulation of gut microbiota represents a new strategy for the treatment of this multifactorial disease. Probiotics appear an attractive option in terms of both efficacy and safety, while prebiotics, synbiotics and antibiotics still need for-mation. Fecal transplant has recently gained a new life as therapeutic option for those patients with an altered gut ecosystem, but data on IBS are scanty and randomized, placebo-controlled studies are required.
Publish Date	2016-01-31 11:48
Citation	Distrutti E, Monaldi L, Ricci P, Fiorucci S. Gut microbiota role in irritable bowel syndrome: New therapeutic strategies. World J Gastroenterol 2016; 22(7): 2219-2241
URL	http://www.wjgnet.com/1007-9327/full/v22/i7/2219.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i7.2219

Full Article (PDF)	WJG-22-2219.pdf
Full Article (Word)	WJG-22-2219.doc
Manuscript File	20143-Review.docx
Answering Reviewers	20143-Answering reivew(s).pdf
Audio Core Tip	20143-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20143-Conflict-of-interest statement.pdf
Copyright License Agreement	20143-Copyright assignment.pdf
Peer-review Report	20143-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20143-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20143-Scientific misconduct check.pdf
Scientific Editor Work List	20143-Scientific editor work list.pdf