Publication Name	World Journal of Cardiology
Manuscript ID	20198
Country	United States

Received	2015-05-29 20:40
Peer-Review Started	2015-06-02 19:02
To Make the First Decision	2015-08-14 15:26
Return for Revision	2015-08-22 16:43
Revised	2015-09-03 20:08
Second Decision	2015-10-13 08:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-27 17:55
Articles in Press	2015-10-27 17:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-17 11:01
Publish the Manuscript Online	2015-12-24 17:39

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Rheumatology
Manuscript Type	Review
Article Title	Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?
Manuscript Source	Invited Manuscript
All Author List	Ashish N Rao, Nayef M Kazzaz and Jason S Knight
Funding Agency and Grant Number	Funding Agency Grant Number NIH K08AR066569 Burroughs Wellcome Fund to Knight JS Security Forces Hospital Program, Ministry of Interior, Riyadh, Saudi Arabia to Kazzaz NM
Corresponding Author	Jason S Knight, MD, PhD, Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, SPC 5680, Ann Arbor, MI 48109-5680, United States. jsknight@umich.edu
Key Words	Thrombosis; Neutrophil extracellular traps; Lupus; Vasculitis; Antiphospholipid syndrome
Core Tip	In order to capture and kill pathogens, neutrophils release webs of chromatin and antimicrobial proteins called neutrophil extracellular traps (NETs). These NETs are also emerging as important players in inflammatory and thrombotic disorders. In this review, we describe the mechanisms by which the various components of NETs promote thrombosis. Further, we highlight emerging evidence that NETs may play a particularly important role when thrombosis occurs in patients with systemic autoimmune diseases such as lupus, vasculitis, and antiphospholipid syndrome.
Publish Date	2015-12-24 17:39
Citation	Rao AN, Kazzaz NM, Knight JS. Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases? World J Cardiol 2015; 7(12): 829-842
URL	http://www.wjgnet.com/1949-8462/full/v7/i12/829.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i12.829

Full Article (PDF)	WJC-7-829.pdf
Full Article (Word)	WJC-7-829.doc
Manuscript File	20198-Review.docx
Answering Reviewers	20198-Answering reviewers.pdf
Audio Core Tip	20198-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20198-Conflict-of-interest statement.PDF
Copyright License Agreement	20198-Copyright assignment.pdf
Peer-review Report	20198-Peer-review(s).pdf
Scientific Misconduct Check	20198-Scientific misconduct check.pdf
Scientific Editor Work List	20198-Scientific editor work list.pdf