Publication Name	World Journal of Gastroenterology
Manuscript ID	2024
Country	Netherlands

Received	2013-01-21 09:28
Peer-Review Started	2013-01-21 09:44
To Make the First Decision	2013-02-21 20:49
Return for Revision	2013-02-25 08:55
Revised
Second Decision	2013-07-05 10:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-05 13:41
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-29 14:31
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Autobiography
Article Title	Children with celiac disease and high tTGA are genetically and phenotypically different
Manuscript Source	Invited Manuscript
All Author List	Amani Mubarak, Eric Spierings, Victorien M Wolters, Henny G Otten, Fiebo JW ten Kate and Roderick HJ Houwen
Funding Agency and Grant Number
Corresponding Author	Amani Mubarak, MD, Department of Pediatric Gastroenterology, University Medical Center Utrecht, Wilhelmina Children's Hospital, PO BOX 85090, 3508 AB Utrecht, The Netherlands. a.mubarak@umcutrecht.nl
Key Words	Celiac disease; Serology; Anti-tissue transglutaminase antibodies; Human leukocyte antigen; Phenotype
Core Tip	We prospectively investigated the differences between celiac disease (CD) (Marsh Ⅲ) patients with tissue-transglutaminase antibody (tTGA) levels ≥ 100 U/mL and patients with lower tTGA levels. We found that patients with high tTGA more often carried multiple CD-associated heterodimers compared with patients with tTGA < 100 U/mL. In addition, high-tTGA patients have more advanced mucosal lesions that are also less patchy. Phenotypically, high-tTGA patients have a lower body weight and more often present with extraintestinal symptoms compared with patients with lower levels of tTGA, who more often have intestinal symptoms. These results provide further evidence that patients with tTGA ≥ 100 U/mL are truly a distinct group with more advanced disease.
Publish Date	2013-11-16 18:29
Citation	Mubarak A, Spierings E, Wolters VM, Otten HG, ten Kate FJW, Houwen RHJ. Children with celiac disease and high tTGA are genetically and phenotypically different. World J Gastroenterol 2013; 19(41): 7114-7120
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/7114.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.7114

Full Article (PDF)	WJG-19-7114.pdf
Manuscript File	2024-Review.docx
Answering Reviewers	2024-Answering reviewers.pdf
Copyright License Agreement	2024-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2024-Language certificate.pdf
Peer-review Report	2024-Peer reviews.pdf
Scientific Editor Work List	2024-Scientific editor work list.doc