Publication Name	World Journal of Nephrology
Manuscript ID	20338
Country	United Kingdom

Received	2015-06-02 09:31
Peer-Review Started	2015-06-02 11:13
To Make the First Decision	2015-06-18 15:36
Return for Revision	2015-06-20 17:28
Revised	2015-06-23 22:21
Second Decision	2015-08-27 11:25
Accepted by Journal Editor-in-Chief	2015-08-28 02:12
Accepted by Executive Editor-in-Chief	2015-08-31 15:11
Articles in Press	2015-08-31 15:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-02 10:41
Publish the Manuscript Online	2015-09-15 08:59

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Review
Article Title	Current management of autosomal dominant polycystic kidney disease
Manuscript Source	Invited Manuscript
All Author List	Jacob A Akoh
Funding Agency and Grant Number
Corresponding Author	Jacob A Akoh, FRCSEd, FRCS (Gen), Consultant General and Transplant Surgeon, South West Transplant Centre, Plymouth Hospitals NHS Trust, Derriford Hospital, Level 04, Plymouth PL6 8DH, United Kingdom. jacob.akoh@nhs.net
Key Words	Autosomal dominant polycystic kidney disease; Native nephrectomy; Cyst decortication; Kidney transplantation; Hypertension; Drug therapy; End stage renal disease; Extrarenal manifestatation; Total kidney volume
Core Tip	Autosomal dominant polycystic kidney disease (ADPKD), the most frequent cause of genetic kidney disease affecting approximately 4 to 7 million individuals worldwide (7%-15% of patients on renal replacement therapy), is a systemic disorder mainly involving the kidney but cysts can also occur in other organs such as the liver, pancreas and arachnoid membrane. This paper discusses radiological evaluation of ADPKD, necessity for screening for intracranial aneurysms and current treatment strategies include reducing: cyclic adenosine monophosphate levels, cell proliferation and fluid secretion. It further discusses the role of surgery in managing ADPKD patients and highlights areas of new research.
Publish Date	2015-09-15 08:59
Citation	Akoh JA. Current management of autosomal dominant polycystic kidney disease. World J Nephrol 2015; 4(4): 468-479
URL	http://www.wjgnet.com/2220-6124/full/v4/i4/468.htm
DOI	http://dx.doi.org/10.5527/wjn.v4.i4.468

Full Article (PDF)	WJN-4-468.pdf
Full Article (Word)	WJN-4-468.doc
Manuscript File	20338-Review.docx
Answering Reviewers	20338-Answering reviewers.pdf
Audio Core Tip	20338-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20338-Conflict-of-interest statement.pdf
Copyright License Agreement	20338-Copyright assignment.pdf
Peer-review Report	20338-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20338-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20338-Scientific misconduct check.pdf
Scientific Editor Work List	20338-Scientific editor work list.pdf