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11/17/2015 12:17:00 PM | Browse: 569 | Download: 691
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 20386
Country/Territory United Kingdom
Received
2015-06-03 09:13
Peer-Review Started
2015-06-05 14:53
To Make the First Decision
2015-07-06 14:48
Return for Revision
2015-07-12 14:38
Revised
2015-07-30 00:31
Second Decision
2015-10-08 12:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-10-19 15:13
Articles in Press
2015-10-19 15:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-26 11:07
Publish the Manuscript Online
2015-11-17 12:17
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Retrospective Cohort Study
Article Title Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
Manuscript Source Invited Manuscript
All Author List Samuel J Tingle, John A Moir and Steven A White
Funding Agency and Grant Number
Corresponding author Steven A White, Professor, HPB and Transplant Consultant, HPB Unit, Freeman Hospital, Freeman Road, Newcastle upon Tyne, Tyne and Wear NE7 7DN, United Kingdom. steven.white@nuth.nhs.uk
Key Words Pancreatic ductal adenocarcinoma; Stroma; Polypharmacy; Calcium channel blockers; Angiotensin Ⅱ receptor blockers; Angiotensin-converting enzyme inhibitors; Aspirin; Pancreaticoduodenectomy; Statins
Core Tip Stromal interactions play a large part in the dismal prognosis of pancreatic cancer. Recent laboratory studies have examined the potential use of common pharmaceuticals, such as calcium channel blocker (CCB), aspirin, angiotensin-converting enzyme inhibi-tors/angiotensin Ⅱ receptor blockers and statins, in inhibiting these protumorigenic stromal interactions. We retrospectively collected data from 164 patients whom underwent a pancreaticoduodenectomy to remove a pancreatic ductal adenocarcinoma, to see if the potential benefits of these drugs translated into increased survival. Our finding that those taking a combination of aspirin and CCB survived over twice as long as those on neither drug, highlights the potential of novel drug combinations to increase survival in pancreatic cancer.
Publish Date 2015-11-17 12:17
Citation Tingle SJ, Moir JA, White SA. Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. World J Gastrointest Pathophysiol 2015; 6(4): 235-242
Url http://www.wjgnet.com/2150-5330/full/v6/i4/235.htm
DOI http://dx.doi.org/10.4291/wjgp.v6.i4.235
Full Article (PDF) WJGP-6-235.pdf
Full Article (Word) WJGP-6-235.doc
Manuscript File 20386-Review.docx
Answering Reviewers 20386-Answering reviewers.pdf
Audio Core Tip 20386-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20386-Conflict-of-interest statement.pdf
Copyright License Agreement 20386-Copyright assignment.pdf
Data Sharing Statement 20386-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 20386-Institutional review board statement.pdf
Peer-review Report 20386-Peer-review(s).pdf
Scientific Misconduct Check 20386-Scientific misconduct check.pdf
Scientific Editor Work List 20386-Scientific editor work list.pdf