Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	20386
Country	United Kingdom

Received	2015-06-03 09:13
Peer-Review Started	2015-06-05 14:53
To Make the First Decision	2015-07-06 14:48
Return for Revision	2015-07-12 14:38
Revised	2015-07-30 00:31
Second Decision	2015-10-08 12:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-19 15:13
Articles in Press	2015-10-19 15:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-26 11:07
Publish the Manuscript Online	2015-11-17 12:17

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Samuel J Tingle, John A Moir and Steven A White
Funding Agency and Grant Number
Corresponding Author	Steven A White, Professor, HPB and Transplant Consultant, HPB Unit, Freeman Hospital, Freeman Road, Newcastle upon Tyne, Tyne and Wear NE7 7DN, United Kingdom. steven.white@nuth.nhs.uk
Key Words	Pancreatic ductal adenocarcinoma; Stroma; Polypharmacy; Calcium channel blockers; Angiotensin Ⅱ receptor blockers; Angiotensin-converting enzyme inhibitors; Aspirin; Pancreaticoduodenectomy; Statins
Core Tip	Stromal interactions play a large part in the dismal prognosis of pancreatic cancer. Recent laboratory studies have examined the potential use of common pharmaceuticals, such as calcium channel blocker (CCB), aspirin, angiotensin-converting enzyme inhibi-tors/angiotensin Ⅱ receptor blockers and statins, in inhibiting these protumorigenic stromal interactions. We retrospectively collected data from 164 patients whom underwent a pancreaticoduodenectomy to remove a pancreatic ductal adenocarcinoma, to see if the potential benefits of these drugs translated into increased survival. Our finding that those taking a combination of aspirin and CCB survived over twice as long as those on neither drug, highlights the potential of novel drug combinations to increase survival in pancreatic cancer.
Publish Date	2015-11-17 12:17
Citation	Tingle SJ, Moir JA, White SA. Role of anti-stromal polypharmacy in increasing survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma. World J Gastrointest Pathophysiol 2015; 6(4): 235-242
URL	http://www.wjgnet.com/2150-5330/full/v6/i4/235.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i4.235

Full Article (PDF)	WJGP-6-235.pdf
Full Article (Word)	WJGP-6-235.doc
Manuscript File	20386-Review.docx
Answering Reviewers	20386-Answering reviewers.pdf
Audio Core Tip	20386-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20386-Conflict-of-interest statement.pdf
Copyright License Agreement	20386-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	20386-Institutional review board statement.pdf
Peer-review Report	20386-Peer-review(s).pdf
Scientific Misconduct Check	20386-Scientific misconduct check.pdf
Scientific Editor Work List	20386-Scientific editor work list.pdf