Publication Name	World Journal of Gastroenterology
Manuscript ID	2049
Country	Japan

Received	2013-01-23 08:56
Peer-Review Started	2013-01-24 12:01
To Make the First Decision	2013-03-04 11:54
Return for Revision	2013-03-08 10:14
Revised	2013-03-11 23:36
Second Decision	2013-06-19 12:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-20 00:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-07-22 16:23
Typeset the Manuscript	2013-07-30 16:09
Publish the Manuscript Online	2013-08-13 11:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors
Manuscript Source	Invited Manuscript
All Author List	Hiroshi Matsumura, Kazushige Nirei, Hitomi Nakamura, Teruhisa Higuchi, Yasuo Arakawa, Masahiro Ogawa, Naohide Tanaka and Mitsuhiko Moriyama
Funding Agency and Grant Number
Corresponding Author	Hiroshi Matsumura, MD, PhD, Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashiku, Tokyo 173-8610, Japan. hsh.matsumura@nifty.com
Key Words	Hepatocellular carcinoma; Irregular regeneration of hepatocytes; Liver fibrosis; Type C chronic liver disease; Histopathology of liver biopsy
Core Tip	To evaluate the histopathological findings of type C liver disease to determine risk factors for the development of hepatocellular carcinoma (HCC), we studied 232 patients, who underwent liver biopsy, with sustained virological response after interferon therapy. We investigated in detail the histopathological findings, and analyzed the findings to determine the risk factors. Consequently, atypical hepatocytes among irregular regeneration of hepatocytes may be an important risk factor for HCC development, along with progression of liver fibrosis. Clarification of atypical hepatocytes as a risk factor of carcinogenesis may aid in the early diagnosis of HCC.
Publish Date	2013-08-13 11:13
Citation	Matsumura H, Nirei K, Nakamura H, Higuchi T, Arakawa Y, Ogawa M, Tanaka N, Moriyama M. Histopathology of type C liver disease for determining hepatocellular carcinoma risk factors. World J Gastroenterol 2013; 19(30): 4887-4896
URL	http://www.wjgnet.com/1007-9327/full/v19/i30/4887.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i30.4887

Full Article (PDF)	WJG-19-4887.pdf
Manuscript File	2049-Review.doc
Answering Reviewers	2049-Answering reviewers.pdf
Copyright License Agreement	2049-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2049-Language certificate.docx
Peer-review Report	2049-Peer review.pdf
Scientific Editor Work List	2049-Scientific editor work list.doc