Publication Name	World Journal of Biological Chemistry
Manuscript ID	20584
Country	United States

Received	2015-06-11 08:26
Peer-Review Started	2015-06-11 21:41
To Make the First Decision	2015-08-16 14:45
Return for Revision	2015-08-25 16:37
Revised	2015-09-05 05:26
Second Decision	2015-09-21 17:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-10-08 18:17
Articles in Press	2015-10-08 18:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:23
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Frontier
Article Title	Discovery and characterization of the first non-coding RNA that regulates gene expression, micF RNA: A historical perspective
Manuscript Source	Invited Manuscript
All Author List	Nicholas Delihas
Funding Agency and Grant Number
Corresponding Author	Nicholas Delihas, Professor Emeritus, Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794-5222, United States. nicholas.delihas@stonybrook.edu
Key Words	Non-coding RNAs; RNA/RNA interaction; Regulation of gene expression; micF RNA; Trans-acting RNA gene
Core Tip	The original discovery and characterization of the first non-coding RNA gene and its transcript was with prokaryotes in the 1980s. At that time the Escherichia coli micF RNA gene was characterized in terms of properties, its promoter region, and activation by environmental stress conditions; and the micF RNA transcript structure as well as the micF RNA/target messenger RNA duplex interaction were elucidated. This occurred over 5 years before the discovery of the first eukaryotic regulatory miRNA, which is not generally recognized. Prokaryotic and eukaryotic non-coding RNAs greatly differ in terms of RNA processing, but the basic principle of an RNA gene locus encoding a regulatory RNA that targets gene expression in trans via RNA/target RNA duplex formation is similar. Thus the concept and discovery of regulatory non-coding RNAs and their functions in messenger RNA inhibition originated with prokaryotes.
Publish Date	2015-11-23 10:19
Citation	Delihas N. Discovery and characterization of the first non-coding RNA that regulates gene expression, micF RNA: A historical perspective. World J Biol Chem 2015; 6(4): 272-280
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/272.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.272

Full Article (PDF)	WJBC-6-272.pdf
Full Article (Word)	WJBC-6-272.doc
Manuscript File	20584-Review.docx
Answering Reviewers	20584-Answering reviewers.pdf
Audio Core Tip	20584-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20584-Conflict-of-interest statement.pdf
Copyright License Agreement	20584-Copyright assignment.pdf
Peer-review Report	20584-Peer-review(s).pdf
Scientific Misconduct Check	20584-Scientific misconduct check.pdf
Scientific Editor Work List	20584-Scientific editor work list.pdf