Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	20649
Country	Italy

Received	2015-06-15 08:30
Peer-Review Started	2015-06-17 08:32
To Make the First Decision	2015-07-27 15:52
Return for Revision	2015-08-04 15:15
Revised	2015-08-08 23:47
Second Decision	2015-10-22 15:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-04 17:17
Articles in Press	2015-11-04 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-10 15:59
Publish the Manuscript Online	2016-01-14 20:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike
Manuscript Source	Invited Manuscript
All Author List	Natale Figura, Luigi Marano, Elena Moretti and Antonio Ponzetto
Funding Agency and Grant Number
Corresponding Author	Natale Figura, Professor, Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, Viale Bracci, 53100 Siena, Italy. natale.figura@unisi.it
Key Words	Helicobacter pylori infection; CagA; CagA gene polymorphism; Haplotype; Human gene mutation; Gene methylation; Gastric carcinoma; Inflammatory cytokine
Core Tip	CagA and the cagA types may play different roles in the intestinal and diffuse histotypes of gastric carcinoma (GC); The current criteria of Helicobacter pylori (H. pylori) strain classification based on their carcinogenic potential gave rise to confusion and should be unified. The possible role of inflammatory cytokine haplotypes in GC development should be reassessed taking into account some host’s factors, the most important being different ethnic origin. Infection by the cagA positive H. pylori genotype may determine an increased inflammatory response and a consequent enhancement of mutagenesis rate, oxidative-stress, reactive oxygen species generation, dysfunction of DNA repair mechanisms, genetic instability and resultant high risk of GC development.
Publish Date	2016-01-14 20:17
Citation	Figura N, Marano L, Moretti E, Ponzetto A. Helicobacter pylori infection and gastric carcinoma: Not all the strains and patients are alike. World J Gastrointest Oncol 2016; 8(1): 40-54
URL	http://www.wjgnet.com/1948-5204/full/v8/i1/40.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i1.40

Full Article (PDF)	WJGO-8-40.pdf
Full Article (Word)	WJGO-8-40.doc
Manuscript File	20649-Review.docx
Answering Reviewers	20649-Answering reviewers.pdf
Audio Core Tip	20649-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20649-Conflict-of-interest statement.pdf
Copyright License Agreement	20649-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20649-Language certificate.pdf
Peer-review Report	20649-Peer-review(s).pdf
Scientific Misconduct Check	20649-Scientific misconduct check.pdf
Scientific Editor Work List	20649-Scientific editor work list.pdf