Publication Name	World Journal of Hypertension
Manuscript ID	20691
Country	Chile

Received	2015-06-16 10:09
Peer-Review Started	2015-06-18 08:42
To Make the First Decision	2015-07-27 18:35
Return for Revision	2015-07-31 17:48
Revised	2015-08-30 04:53
Second Decision	2015-11-23 09:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-04 16:41
Articles in Press	2015-12-04 16:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-19 11:07
Publish the Manuscript Online	2016-02-23 22:08

ISSN	2220-3168 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Therapeutics Advances
Article Title	Regression of cardiovascular remodeling in hypertension: Novel relevant mechanisms
Manuscript Source	Invited Manuscript
All Author List	Jorge E Jalil and María P Ocaranza
Funding Agency and Grant Number	Funding Agency Grant Number Comisión Nacional de Investigación Científica y Tecnológica (CONICYT, Chile) FONDECYT 1121060 (to JEJ and MPO) Comisión Nacional de Investigación Científica y Tecnológica (CONICYT, Chile) FONDEF D11I1122 (to MPO and JEJ) Comisión Nacional de Investigación Científica y Tecnológica (CONICYT, Chile) FONDAP 15130011 (to MPO)
Corresponding Author	Jorge E Jalil, MD, Professor of Medicine, P Universidad Católica de Chile, School of Medicine, Division of Cardiovascular Diseases. Marcoleta 367 Piso 8, Santiago 758-0150, Chile. jjalil@med.puc.cl
Key Words	Remodeling; Hypertrophy; Rho kinase; Myosin phosphatase target subunit 1; Angiotensin; Angiotensin1-9; Chymase; Angio­tensin1-7
Core Tip	Antihypertensive treatment normalizes high blood pressure, partially reverses organ damage, and reduces the incidence of heart and renal failure. However, residual organ damage and high risk for cardiovascular events still persist. We review here novel relevant mechanisms of cardiovascular damage in hypertension, their role and evidence in prevention/regression of cardiovascular remodeling and their possible clinical impact. We focus on the signaling pathway RhoA/Rho kinase, on the impact of the vasodilatory peptides from the renin angiotensin system and some insights on the role of estrogens and myocardial chymase in cardiovascular remodeling due to hypertension.
Publish Date	2016-02-23 22:08
Citation	Jalil JE, Ocaranza MP. Regression of cardiovascular remodeling in hypertension: Novel relevant mechanisms. World J Hypertens 2016; 6(1): 1-17
URL	http://www.wjgnet.com/2220-3168/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.5494/wjh.v6.i1.1

Full Article (PDF)	WJH-6-1.pdf
Full Article (Word)	WJH-6-1.doc
Manuscript File	20691-Review.docx
Answering Reviewers	20691-Answering reviewers.pdf
Audio Core Tip	20691-Audio core tip.wav
Conflict-of-Interest Disclosure Form	20691-Conflict-of-interest statement .pdf
Copyright License Agreement	20691-Copyright assignment.pdf
Peer-review Report	20691-Peer-review(s).pdf
Scientific Misconduct Check	20691-Scientific misconduct check.pdf
Scientific Editor Work List	20691-Scientific editor work list.pdf