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10/30/2015 11:57:00 AM | Browse: 1053 | Download: 2000
Publication Name World Journal of Hepatology
Manuscript ID 20709
Country/Territory Brazil
Received
2015-06-17 08:28
Peer-Review Started
2015-06-17 19:57
To Make the First Decision
2015-07-03 16:44
Return for Revision
2015-07-13 15:58
Revised
2015-07-28 22:08
Second Decision
2015-09-21 17:49
Accepted by Journal Editor-in-Chief
2015-09-22 21:31
Accepted by Company Editor-in-Chief
2015-09-30 18:48
Articles in Press
2015-09-30 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-19 08:54
Publish the Manuscript Online
2015-10-30 11:57
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice
Manuscript Source Invited Manuscript
All Author List Simone Coghetto Acedo, Cintia Rabelo e Paiva Caria, Érica Martins Ferreira Gotardo, José Aires Pereira, José Pedrazzoli, Marcelo Lima Ribeiro and Alessandra Gambero
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP 2011/00518-4
Corresponding Author Alessandra Gambero, PhD, Clinical Pharmacology and Gastroenterology Unit, São Francisco Univer¬sity Medical School, Av. São Francisco de Assis 218, Bragança Paulista SP 12916-900, Brazil. alessandra.gambero@usf.edu.br
Key Words Pentoxifylline; Steatosis; Obesity; Adipose tissue; Adipokine; Tumor necrosis factor-a
Core Tip Pentoxifylline is prescribed to patients with severe alcoholic hepatitis, which suggest that this drug could also be beneficial to non-alcoholic steatohepatitis (NASH) patients. However, experimental results with pentoxifylline have shown conflicting data depending on the NASH model employed. Considering that obesity is strongly associated with the development of NASH, our study evaluated the effects of pentoxifylline in a high-fat diet induced obesity model. Our results showed that pentoxifylline was beneficial in obesity-associated NASH improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline treatment resulted in undesirable effects in adipose tissue and liver inflammatory markers in lean mice.
Publish Date 2015-10-30 11:57
Citation Acedo SC, Caria CRP, Gotardo ÉMF, Pereira JA, Pedrazzoli J, Ribeiro ML, Gambero A. Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice. World J Hepatol 2015; 7(24): 2551-2558
URL http://www.wjgnet.com/1948-5182/full/v7/i24/2551.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i24.2551
Full Article (PDF) WJH-7-2551.pdf
Full Article (Word) WJH-7-2551.doc
Manuscript File 20709-Review.docx
Answering Reviewers 20709-Answering reviewers.pdf
Audio Core Tip 20709-Audio core tip.wma
Biostatistics Review Certificate 20709-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 20709-Conflict-of-interest statement.pdf
Copyright License Agreement 20709-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 20709-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 20709-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 20709-Language certificate.pdf
Peer-review Report 20709-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 20709-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 20709-Scientific misconduct check.pdf
Scientific Editor Work List 20709-Scientific editor work list.pdf