Publication Name	World Journal of Hepatology
Manuscript ID	20709
Country	Brazil

Received	2015-06-17 08:28
Peer-Review Started	2015-06-17 19:57
To Make the First Decision	2015-07-03 16:44
Return for Revision	2015-07-13 15:58
Revised	2015-07-28 22:08
Second Decision	2015-09-21 17:49
Accepted by Journal Editor-in-Chief	2015-09-22 21:31
Accepted by Executive Editor-in-Chief	2015-09-30 18:48
Articles in Press	2015-09-30 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-19 08:54
Publish the Manuscript Online	2015-10-30 11:57

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice
Manuscript Source	Invited Manuscript
All Author List	Simone Coghetto Acedo, Cintia Rabelo e Paiva Caria, Érica Martins Ferreira Gotardo, José Aires Pereira, José Pedrazzoli, Marcelo Lima Ribeiro and Alessandra Gambero
Funding Agency and Grant Number	Funding Agency Grant Number Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP 2011/00518-4
Corresponding Author	Alessandra Gambero, PhD, Clinical Pharmacology and Gastroenterology Unit, São Francisco Univer¬sity Medical School, Av. São Francisco de Assis 218, Bragança Paulista SP 12916-900, Brazil. alessandra.gambero@usf.edu.br
Key Words	Pentoxifylline; Steatosis; Obesity; Adipose tissue; Adipokine; Tumor necrosis factor-a
Core Tip	Pentoxifylline is prescribed to patients with severe alcoholic hepatitis, which suggest that this drug could also be beneficial to non-alcoholic steatohepatitis (NASH) patients. However, experimental results with pentoxifylline have shown conflicting data depending on the NASH model employed. Considering that obesity is strongly associated with the development of NASH, our study evaluated the effects of pentoxifylline in a high-fat diet induced obesity model. Our results showed that pentoxifylline was beneficial in obesity-associated NASH improving liver and adipose tissue inflammation. Unexpectedly, pentoxifylline treatment resulted in undesirable effects in adipose tissue and liver inflammatory markers in lean mice.
Publish Date	2015-10-30 11:57
Citation	Acedo SC, Caria CRP, Gotardo ÉMF, Pereira JA, Pedrazzoli J, Ribeiro ML, Gambero A. Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice. World J Hepatol 2015; 7(24): 2551-2558
URL	http://www.wjgnet.com/1948-5182/full/v7/i24/2551.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i24.2551

Full Article (PDF)	WJH-7-2551.pdf
Full Article (Word)	WJH-7-2551.doc
Manuscript File	20709-Review.docx
Answering Reviewers	20709-Answering reviewers.pdf
Audio Core Tip	20709-Audio core tip.wma
Biostatistics Review Certificate	20709-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	20709-Conflict-of-interest statement.pdf
Copyright License Agreement	20709-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	20709-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	20709-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	20709-Language certificate.pdf
Peer-review Report	20709-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20709-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20709-Scientific misconduct check.pdf
Scientific Editor Work List	20709-Scientific editor work list.pdf