Publication Name	World Journal of Gastroenterology
Manuscript ID	20815
Country	Canada

Received	2015-06-23 08:31
Peer-Review Started	2015-06-26 09:57
To Make the First Decision	2015-07-20 14:01
Return for Revision	2015-08-02 16:30
Revised	2015-08-17 23:16
Second Decision	2015-10-14 09:04
Accepted by Journal Editor-in-Chief	2015-10-14 17:28
Accepted by Executive Editor-in-Chief	2015-10-26 18:03
Articles in Press	2015-10-26 18:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-30 17:52
Publish the Manuscript Online	2015-11-18 12:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Topic Highlights
Article Title	Th17 plasticity and its changes associated with inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Aito Ueno, Abhisek Ghosh, Daniel Hung, Ji Li and Humberto Jijon
Funding Agency and Grant Number
Corresponding Author	Dr. Aito Ueno, Department of Medicine, University of Calgary, HSC1838, 2500 University Dr. NW, Calgary T2N 1N4, Alberta, Canada. aueno@ucalgary.ca
Key Words	Th7; Regulatory T cells; T cell plasticity; Inflammatory bowel disease
Core Tip	Recently, two innovative clinical failures in inflammatory bowel disease which sought to manipulate T helper (Th) subsets via either transplantation of regulatory T cells or interleukin-17 blockade using secukinumab, suggest that altering the balance between inflammatory and regulatory subsets in inflammatory bowel diseases (IBD) may be more complex than previously thought. One reason may be the flexible nature of T helper subset commitment, otherwise referred to as plasticity. Here we discuss plasticity between regulatory and inflammatory subsets in T helper CD4+ cells, especially Th17 cell subset, and the potential to therapeutically target this process in human IBD.
Publish Date	2015-11-18 12:39
Citation	Ueno A, Ghosh A, Hung D, Li J, Jijon H. Th17 plasticity and its changes associated with inflammatory bowel disease. World J Gastroenterol 2015; 21(43): 12283-12295
URL	http://www.wjgnet.com/1007-9327/full/v21/i43/12283.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i43.12283

Full Article (PDF)	WJG-21-12283.pdf
Full Article (Word)	WJG-21-12283.doc
Manuscript File	20815-Review.docx
Answering Reviewers	20815-Answering reviewers.pdf
Audio Core Tip	20815-Audio core tip.mp3
Copyright License Agreement	20815-Copyright assignment.pdf
Peer-review Report	20815-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20815-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20815-Scientific misconduct check.pdf
Scientific Editor Work List	20815-Scientific editor work list.pdf