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Articles Published Processes
12/15/2015 5:36:00 PM | Browse: 971 | Download: 2034
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Received |
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2015-06-24 10:28 |
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Peer-Review Started |
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2015-06-29 11:48 |
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To Make the First Decision |
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2015-08-16 17:00 |
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Return for Revision |
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2015-08-22 16:49 |
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Revised |
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2015-09-03 10:30 |
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Second Decision |
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2015-11-17 15:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-02 14:07 |
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Articles in Press |
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2015-12-02 14:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-10 09:44 |
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Publish the Manuscript Online |
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2015-12-15 17:37 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
p38 mitogen-activated protein kinase regulates type-I vs type-II phenotyping of human vascular endothelial cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Masako Nakahara, Miwako Nishio, Koichi Saeki, Akira Yuo and Kumiko Saeki |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Health, Labour and Welfare of Japan |
KHD1017 |
| JST, PRESTO |
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| Corresponding Author |
Kumiko Saeki, MD, PhD, Division Chief, Department of Disease Control, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo 162-8655, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp
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| Key Words |
vascular endothelial cells; vascular smooth muscle cells; proteomic kinase assay; p38α mitogen-activated protein kinase; regulator of G-protein signaling 5; sphingosine-1-phosphate; N-cadherin |
| Core Tip |
We previously reported that human vascular endothelial cells (VECs) are categorized into two types by their effects on the proliferation of vascular smooth muscle cells and the expressions of regulator of G-protein signaling 5 (RGS5): Pro-proliferative RGS5high (type-I) and anti-proliferative RGS5low (type-II) VECs. Performing proteomic kinase assays and inhibitor studies, we show here that p38 mitogen-activated protein kinase (p38 MAPK) is the crucial kinase that determines VEC phenotyping at the downstream of RGS5. Not only RGS5 overexpression suppressed p38 MAPK activities but also p38 MAPK inhibitions up-regulated RGS5 expression, indicating that “RGS5 induction” and “p38 MAPK inhibition” creates a vicious cycle in “type-II to type-I” conversions of human VECs.
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| Publish Date |
2015-12-15 17:37 |
| Citation |
Nakahara M, Nishio M, Saeki K, Yuo A, Saeki K. p38 mitogen-activated protein kinase regulates type-I vs type-II phenotyping of human vascular endothelial cells. World J Transl Med 2015; 4(3): 101-112 |
| URL |
http://www.wjgnet.com/2220-6132/full/v4/i3/101.htm |
| DOI |
http://dx.doi.org/10.5528/wjtm.v4.i3.101 |
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