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12/15/2015 5:36:00 PM | Browse: 870 | Download: 1638
Publication Name World Journal of Translational Medicine
Manuscript ID 20825
Country Japan
Received
2015-06-24 10:28
Peer-Review Started
2015-06-29 11:48
To Make the First Decision
2015-08-16 17:00
Return for Revision
2015-08-22 16:49
Revised
2015-09-03 10:30
Second Decision
2015-11-17 15:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-02 14:07
Articles in Press
2015-12-02 14:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-10 09:44
Publish the Manuscript Online
2015-12-15 17:37
ISSN 2220-6132 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research & Experimental Medicine
Manuscript Type Basic Study
Article Title p38 mitogen-activated protein kinase regulates type-I vs type-II phenotyping of human vascular endothelial cells
Manuscript Source Invited Manuscript
All Author List Masako Nakahara, Miwako Nishio, Koichi Saeki, Akira Yuo and Kumiko Saeki
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Health, Labour and Welfare of Japan KHD1017
JST, PRESTO
Corresponding Author Kumiko Saeki, MD, PhD, Division Chief, Department of Disease Control, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo 162-8655, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp
Key Words vascular endothelial cells; vascular smooth muscle cells; proteomic kinase assay; p38α mitogen-activated protein kinase; regulator of G-protein sig­naling 5; sphingosine-1-phosphate; N-cadherin
Core Tip We previously reported that human vascular endothelial cells (VECs) are categorized into two types by their effects on the proliferation of vascular smooth muscle cells and the expressions of regulator of G-protein signaling 5 (RGS5): Pro-proliferative RGS5high (type-I) and anti-proliferative RGS5low (type-II) VECs. Performing proteomic kinase assays and inhibitor studies, we show here that p38 mitogen-activated protein kinase (p38 MAPK) is the crucial kinase that determines VEC phenotyping at the downstream of RGS5. Not only RGS5 overexpression suppressed p38 MAPK activities but also p38 MAPK inhibitions up-regulated RGS5 expression, indicating that “RGS5 induction” and “p38 MAPK inhibition” creates a vicious cycle in “type-II to type-I” conversions of human VECs.
Publish Date 2015-12-15 17:37
Citation Nakahara M, Nishio M, Saeki K, Yuo A, Saeki K. p38 mitogen-activated protein kinase regulates type-I vs type-II phenotyping of human vascular endothelial cells. World J Transl Med 2015; 4(3): 101-112
URL http://www.wjgnet.com/2220-6132/full/v4/i3/101.htm
DOI http://dx.doi.org/10.5528/wjtm.v4.i3.101
Full Article (PDF) WJTM-4-101.pdf
Full Article (Word) WJTM-4-101.doc
Manuscript File 20825-Review.docx
Answering Reviewers 20825-Answering reviewers.pdf
Audio Core Tip 20825-Audio core tip.wma
Biostatistics Review Certificate 20825-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 20825-Conflict-of-interest statement.pdf
Copyright License Agreement 20825-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 20825-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 20825-Language certificate.pdf
Supplementary Material 20825-Supplementary material.pdf
Peer-review Report 20825-Peer-review(s).pdf
Scientific Misconduct Check 20825-Scientific misconduct check.pdf
Scientific Editor Work List 20825-Scientific editor work list.pdf