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Articles Published Processes
12/15/2015 5:36:00 PM | Browse: 993 | Download: 1767
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Received |
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2015-06-24 10:28 |
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Peer-Review Started |
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2015-06-29 12:09 |
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To Make the First Decision |
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2015-08-16 17:29 |
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Return for Revision |
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2015-08-25 20:07 |
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Revised |
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2015-09-08 11:07 |
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Second Decision |
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2015-11-02 14:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-11-11 17:58 |
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Articles in Press |
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2015-11-11 17:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-10 09:46 |
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Publish the Manuscript Online |
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2015-12-15 17:37 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Pro- vs anti-stenotic capacities of type-I vs type-II human induced pluripotent-derived endothelial cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Miwako Nishio, Masako Nakahara, Koichi Saeki, Katsuhito Fujiu, Hiroshi Iwata, Ichiro Manabe, Akira Yuo and Kumiko Saeki |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Health, Labour and Welfare of Japan |
KHD1017 |
| JST, PRESTO |
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| Corresponding Author |
Kumiko Saeki, MD, PhD, Division Chief, Department of Disease Control, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjukuiku, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp
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| Key Words |
Vascular endothelial cells; Vasa vasorum; Arteriostenosis; Wire injury; Human induced pluripotent stem cells |
| Core Tip |
We previously reported that human vascular endothelial cells (VECs) were classified into two categories by their in vitro effects on the proliferation of vascular smooth muscle cells: Pro-proliferative VECs (type-I) and anti-proliferative VECs (type-II). Applying our new technique to transplant human VECs onto the luminal surface of endothelial layer-removed murine arteries, the in vivo relevance of the concept for VEC categorization was validated. Transplantation of pro-proliferative VECs (type-I) resulted in total stenosis while that of anti-proliferative VECs (type-II) completely blocked the development of arteriostenosis. Thus, pro-stenosis (type-I) and anti-stenotic (type-II) capacities were verified in vivo.
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| Publish Date |
2015-12-15 17:37 |
| Citation |
Nishio M, Nakahara M, Saeki K, Fujiu K, Iwata H, Manabe I, Yuo A, Saeki K. Pro- vs anti-stenotic capacities of type-I vs type-II human induced pluripotent-derived endothelial cells. World J Transl Med 2015; 4(3): 113-122 |
| URL |
http://www.wjgnet.com/2220-6132/full/v4/i3/113.htm |
| DOI |
http://dx.doi.org/10.5528/wjtm.v4.i3.113 |
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