Publication Name	World Journal of Biological Chemistry
Manuscript ID	20881
Country	United States

Received	2015-06-25 10:09
Peer-Review Started	2015-06-25 11:22
To Make the First Decision	2015-08-16 17:00
Return for Revision	2015-08-21 18:05
Revised	2015-09-02 06:41
Second Decision	2015-09-24 17:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-04 17:26
Articles in Press	2015-11-04 17:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 20:05
Publish the Manuscript Online	2016-02-25 19:30

ISSN	1949-8454 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Microbiology
Manuscript Type	Review
Article Title	Yersinia type Ⅲ effectors perturb host innate immune responses
Manuscript Source	Invited Manuscript
All Author List	Khavong Pha and Lorena Navarro
Funding Agency and Grant Number	Funding Agency Grant Number The ASM Robert D Watkins Graduate Fellowship and UC Davis Hellman Fellowship
Corresponding Author	Lorena Navarro, PhD, Department of Microbiology and Molecular Genetics, University of California, One Shields Avenue, 255 Briggs Hall, Davis, CA 95616, United States. lonavarro@ucdavis.edu
Key Words	Type Ⅲ secretion; Yersinia; Effectors; Innate; Virulence
Core Tip	The study of Yersinia type Ⅲ secretion system effector proteins has provided critical insights into bacterial pathogenic strategies and host innate immune responses. Identification of the crystal structure of YpkA revealed how a bacterial effector can counteract phagocytosis at multiple levels including inhibition of actin polymerization by sequestering actin, inhibition of actin signaling molecules via both its kinase and dissociation-like inhibitor domains, and inhibition of actin-cytoskeletal components via phosphorylation. YpkA/YopO multisite autophosphorylation may allow YpkA/YopO to bypass regulation by host phosphatases and thus prolong its ability to interfere with phagocytosis. Additionally, an emerging theme is the role of caspases in anti-Yersinia host defenses.
Publish Date	2016-02-25 19:30
Citation	Pha K, Navarro L. Yersinia type III effectors perturb host innate immune responses. World J Biol Chem 2016; 7(1): 1-13
URL	http://www.wjgnet.com/1949-8454/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.4331/wjbc.v7.i1.1

Full Article (PDF)	WJBC-7-1.pdf
Full Article (Word)	WJBC-7-1.doc
Manuscript File	20881-Review.doc
Answering Reviewers	20881-Answering reviewers.pdf
Audio Core Tip	20881-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20881-Conflict-of-interest statement.pdf
Copyright License Agreement	20881-Copyright assignment.pdf
Peer-review Report	20881-Peer-review(s).pdf
Scientific Misconduct Check	20881-Scientific misconduct check.pdf
Scientific Editor Work List	20881-Scientific editor work list.pdf