Publication Name	World Journal of Immunology
Manuscript ID	20956
Country	United States

Received	2015-06-27 10:10
Peer-Review Started	2015-06-27 19:00
First Decision by Editorial Office Director
Return for Revision	2015-08-02 20:06
Revised	2015-08-19 01:46
Publication Fee Transferred
Second Decision by Editor	2015-11-04 18:04
Second Decision by Editor-in-Chief	2015-11-04 23:43
Final Decision by Editorial Office Director	2015-11-17 08:37
Articles in Press	2015-11-17 08:37
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-18 16:11
Publish the Manuscript Online	2015-11-27 16:41

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Review
Article Title	RNA polymerases in plasma cells trav-ELL2 the beat of a different drum
Manuscript Source	Invited Manuscript
All Author List	Sage M Smith, Nolan T Carew and Christine Milcarek
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation MCB-0842725 National Institutes of Health shared resources Grant P30CA047904 School of Medicine and Department of Immunology
Corresponding Author	Dr. Christine Milcarek, PhD, Professor of Immunology, Department of Immunology, School of Medicine, University of Pittsburgh, 200 Lothrop St., Pittsburgh, PA 15213, United States. milcarek@pitt.edu
Key Words	Interferon regulatory factor 4; Antibody secreting cells; B cell differentiation; ELL2; Secretory-specific antibody; B-lymphocyte-induced maturation protein 1; OCA-B; Super elongation complex; Xbp-1; Mammalian target of rapamycin
Core Tip	B cell differentiation to antibody secreting cells is a highly regulated, complex process facilitated by factors such as interferon regulatory factor 4, Blimp-1, OCA-B, Xbp1, and mammalian target of rapamycin. This results in a switch in immunoglobulin mRNA processing from the membrane-bound to the secretory-specific form, occurring when ELL2 releases RNAP-Ⅱ pausing during transcription elongation and causes exon skipping and proximal poly(A) site choice.
Publish Date	2015-11-27 16:41
Citation	Smith SM, Carew NT, Milcarek C. RNA polymerases in plasma cells trav-ELL2 the beat of a different drum. World J Immunol 2015; 5(3): 99-112
URL	http://www.wjgnet.com/2219-2824/full/v5/i3/99.htm
DOI	http://dx.doi.org/10.5411/wji.v5.i3.99

Full Article (PDF)	WJI-5-99.pdf
Full Article (Word)	WJI-5-99.doc
Manuscript File	20956-Review.docx
Answering Reviewers	20956-Answering reviewers.pdf
Audio Core Tip	20956-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20956-Conflict-of-interest statement.pdf
Copyright License Agreement	20956-Copyright assignment.pdf
Peer-review Report	20956-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20956-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20956-Scientific misconduct check.pdf
Scientific Editor Work List	20956-Scientific editor work list.pdf