Publication Name	World Journal of Gastroenterology
Manuscript ID	21061
Country	Spain

Received	2015-06-29 16:24
Peer-Review Started	2015-07-01 18:07
First Decision by Editorial Office Director
Return for Revision	2015-07-28 11:33
Revised	2015-08-17 21:56
Publication Fee Transferred
Second Decision by Editor	2015-09-23 19:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-09-30 09:01
Articles in Press	2015-09-30 09:01
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-27 10:21
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management
Manuscript Source	Invited Manuscript
All Author List	Sara Blasco-Algora, José Masegosa-Ataz, María Luisa Gutiérrez-García, Sonia Alonso-López and Conrado M Fernández-Rodríguez
Funding Agency and Grant Number
Corresponding Author	Conrado M Fernandez-Rodriguez, MD, Service of Gastroenterology, Hospital Universitario Fundación, Alcorcón, Av Budapest-1, 28922 Alcorcón, Madrid, Spain. cfernandez@fhalcorcon.es
Key Words	Acute on-chronic liver failure; Immune dysfunction; Systemic inflammatory response; Hepatic encephalopathy; Hepatorenal syndrome; Acute decompensation of cirrhosis; Liver failure; Organ failure; Severity score; Chronic liver failure-sequential organ failure assessment
Core Tip	Acute on-chronic liver failure is a newly recognized syndrome characterized by acute deterioration of a compensated or decompensated chronic liver disease, leading to organ failure, and a mortality rate ≥ 15% at 28-d. Pathogenesis involves an exaggerated systemic inflammatory response in the setting of immune dysregulation and oxidative stress. Alcohol is a frequent precipitating factor seen most commonly in the West, and untreated hepatitis B virus infection is more prevalently seen in the East. However, it must be noted, that specific precipitant factors cannot be established in up to the 40% of cases. Recent prospective work has generated data on definition, prevalence, precipitating factors and scoring systems. Treatment of precipitant factors, complications, organ failure support, and liver transplantation are the current therapeutic options.
Publish Date	2015-11-11 13:34
Citation	Blasco-Algora S, Masegosa-Ataz J, Gutiérrez-García ML, Alonso-López S, Fernández-Rodríguez CM. Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management. World J Gastroenterol 2015; 21(42): 12125-12140
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12125.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12125

Full Article (PDF)	WJG-21-12125.pdf
Full Article (Word)	WJG-21-12125.doc
Manuscript File	21061-Review.docx
Answering Reviewers	21061-Answering reviewers.pdf
Audio Core Tip	21061-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21061-Conflict-of-interest statement.pdf
Copyright License Agreement	21061-Copyright assignment.pdf
Peer-review Report	21061-Peer-review(s).pdf
Scientific Misconduct Check	21061-Scientific misconduct check.pdf
Scientific Editor Work List	21061-Scientific editor work list.pdf