Publication Name	World Journal of Hepatology
Manuscript ID	21084
Country	Italy

Received	2015-06-30 11:59
Peer-Review Started	2015-06-30 21:54
To Make the First Decision	2015-09-16 13:52
Return for Revision	2015-09-18 16:12
Revised	2015-09-27 19:53
Second Decision	2015-11-02 14:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-17 09:19
Articles in Press	2015-11-17 09:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-19 15:03
Publish the Manuscript Online	2015-11-27 17:14

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Clinical significance of hepatitis B surface antigen mutants
Manuscript Source	Invited Manuscript
All Author List	Nicola Coppola, Lorenzo Onorato, Carmine Minichini, Giovanni Di Caprio, Mario Starace, Caterina Sagnelli and Evangelista Sagnelli
Funding Agency and Grant Number
Corresponding Author	Nicola Coppola, MD, PhD, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via: L. Armanni 5, 80131 Naples, Italy. nicola.coppola@unina2.it
Key Words	Hepatitis B virus infection; Vaccine escape; Immune escape hepatocellular carcinoma; Hepatitis B surface antigen mutants
Core Tip	Antibodies to the hepatitis B surface antigen (HBsAg) produced in response to hepatitis B virus infection or vaccination and those used in diagnostic assays to detect this antigen in serum are both directed against the ‘‘a’’ determinant region, common to all subtypes of the virus. Mutations occurring on the loops of the “a” determinant may be responsible for the lack of protection in immunized patients and in those individuals receiving hepatitis B immune globulin or for failed detection of HBsAg using commercial diagnostic assays. There is growing evidence in the last decade of the association between HBsAg mutations and the development of hepatocellular carcinoma (HCC), suggesting that the pre-S1 or pre-S2 large deletions are those prevalently associated with the development of HCC. This review article will focus on the clinical impact of the various HBsAg mutants.
Publish Date	2015-11-27 17:14
Citation	Coppola N, Onorato L, Minichini C, Di Caprio G, Starace M, Sagnelli C, Sagnelli E. Clinical significance of hepatitis B surface antigen mutants. World J Hepatol 2015; 7(27): 2729-2739
URL	http://www.wjgnet.com/1948-5182/full/v7/i27/2729.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i27.2729

Full Article (PDF)	WJH-7-2729.pdf
Full Article (Word)	WJH-7-2729.doc
Manuscript File	21084-Review.docx
Answering Reviewers	21084-Answering reviewers.pdf
Audio Core Tip	21084-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21084-Conflict-of-interest statement.pdf
Copyright License Agreement	21084-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21084-Language certificate.pdf
Peer-review Report	21084-Peer-review(s).pdf
Scientific Misconduct Check	21084-Scientific misconduct check.pdf
Scientific Editor Work List	21084-Scientific editor work list.pdf