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1/31/2016 4:11:00 PM | Browse: 407 | Download: 725
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 21138
Country of Manuscript Source United States
2015-06-29 14:51
Peer-Review Started
2015-07-02 21:46
To Make the First Decision
2015-09-16 09:12
Return for Revision
2015-09-22 16:47
2015-10-10 00:27
Second Decision
2015-12-07 09:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-18 16:52
Articles in Press
2015-12-18 16:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-22 13:23
Publish the Manuscript Online
2016-01-31 16:11
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Biochemistry and Molecular Biology
Manuscript type Basic Study
Article Title Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine
Manuscript Source Invited Manuscript
All Author List Emily M Bradford, Kanimozhi Vairamani and Gary E Shull
Funding Agency and Grant Number
Correspondence To ary E Shull, PhD, Professor, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, United States. shullge@ucmail.uc.edu
Keywords SLC12a2; Chemosensory; Chemosensitivity; Gastrointestinal; Dyspepsia
Core Tip The NKCC1 Na+-K+-2Cl- cotransporter is a major mechanism of Cl- uptake in support of secretion. To investigate its intestinal functions we analyzed mRNA expression changes in NKCC1-null intestines. Differentially expressed genes included digestive enzymes and a large number of olfactory and other G-protein coupled receptors that function in chemical sensing. This suggests that loss of NKCC1 affects not only secretion, but also digestion and chemosensing of components of the intestinal contents. The results likely have relevance to recent evidence showing that mutations in the human NKCC1 gene cause unexplained food intolerance and failure of intestinal function requiring parenteral nutrition.
Publish Date 2016-01-31 16:11
Citation Bradford EM, Vairamani K, Shull GE. Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine. World J Gastrointest Pathophysiol 2016; 7(1): 138-149
Url http://www.wjgnet.com/2150-5330/full/v7/i1/138.htm
DOI http://dx.doi.org/10.4291/wjgp.v7.i1.138
Full Article (PDF) WJGP-7-138.pdf
Full Article (Word) WJGP-7-138.doc
Manuscript File 21138-Review.docx
Answering Reviewers 21138-Answering reviewers.pdf
Audio Core Tip 21138-Audio core tip.mp3
Biostatistics Review Certificate 21138-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21138-Conflict-of-interest statement.pdf
Copyright License Agreement 21138-Copyright assignment.pdf
Data Sharing Statement 21138-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 21138-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 21138-Institutional review board statement.pdf
Peer-review Report 21138-Peer-review(s).pdf
Scientific Misconduct Check 21138-Scientific misconduct check.pdf
Scientific Editor Work List 21138-Scientific editor work list.pdf