Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	21138
Country	United States

Received	2015-06-29 14:51
Peer-Review Started	2015-07-02 21:46
To Make the First Decision	2015-09-16 09:12
Return for Revision	2015-09-22 16:47
Revised	2015-10-10 00:27
Second Decision	2015-12-07 09:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-18 16:52
Articles in Press	2015-12-18 16:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-22 13:23
Publish the Manuscript Online	2016-01-31 16:11

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Basic Study
Article Title	Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine
Manuscript Source	Invited Manuscript
All Author List	Emily M Bradford, Kanimozhi Vairamani and Gary E Shull
Funding Agency and Grant Number
Corresponding Author	ary E Shull, PhD, Professor, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, United States. shullge@ucmail.uc.edu
Key Words	SLC12a2; Chemosensory; Chemosensitivity; Gastrointestinal; Dyspepsia
Core Tip	The NKCC1 Na+-K+-2Cl- cotransporter is a major mechanism of Cl- uptake in support of secretion. To investigate its intestinal functions we analyzed mRNA expression changes in NKCC1-null intestines. Differentially expressed genes included digestive enzymes and a large number of olfactory and other G-protein coupled receptors that function in chemical sensing. This suggests that loss of NKCC1 affects not only secretion, but also digestion and chemosensing of components of the intestinal contents. The results likely have relevance to recent evidence showing that mutations in the human NKCC1 gene cause unexplained food intolerance and failure of intestinal function requiring parenteral nutrition.
Publish Date	2016-01-31 16:11
Citation	Bradford EM, Vairamani K, Shull GE. Differential expression of pancreatic protein and chemosensing receptor mRNAs in NKCC1-null intestine. World J Gastrointest Pathophysiol 2016; 7(1): 138-149
URL	http://www.wjgnet.com/2150-5330/full/v7/i1/138.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i1.138

Full Article (PDF)	WJGP-7-138.pdf
Full Article (Word)	WJGP-7-138.doc
Manuscript File	21138-Review.docx
Answering Reviewers	21138-Answering reviewers.pdf
Audio Core Tip	21138-Audio core tip.mp3
Biostatistics Review Certificate	21138-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21138-Conflict-of-interest statement.pdf
Copyright License Agreement	21138-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	21138-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	21138-Institutional review board statement.pdf
Peer-review Report	21138-Peer-review(s).pdf
Scientific Misconduct Check	21138-Scientific misconduct check.pdf
Scientific Editor Work List	21138-Scientific editor work list.pdf