Publication Name	World Journal of Cardiology
Manuscript ID	21192
Country	Italy

Received	2015-06-30 15:43
Peer-Review Started
To Make the First Decision
Return for Revision
Revised	2015-09-21 21:59
Second Decision	2015-10-13 08:45
Accepted by Journal Editor-in-Chief	2015-10-13 13:29
Accepted by Company Editor-in-Chief	2015-10-27 18:22
Articles in Press	2015-10-27 18:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-09 16:36
Publish the Manuscript Online	2015-12-24 17:39

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Peripheral reflex feedbacks in chronic heart failure: Is it time for a direct treatment?
Manuscript Source	Invited Manuscript
All Author List	Alberto Giannoni, Gianluca Mirizzi, Alberto Aimo, Michele Emdin and Claudio Passino
Funding Agency and Grant Number
Corresponding Author	Claudio Passino, MD, Division of Cardiology and Cardiovascular Medicine, Fondazione Toscana Gabriele Monasterio, via Giuseppe Moruzzi 1, 56124 Pisa, Italy. passino@ftgm.it
Key Words	Baroreflex; Chemoreflex; Ergoreflex; Heart failure; Sympathetic system; Neurohormones
Core Tip	At the borders of the neurohormonal model of heart failure (HF), a partially unexplored path trough the maze of HF pathophysiology is represented by the feedback systems. There are several evidences, from both animal studies and humans reports, that the deregulation of baro-, ergo- and chemo-reflexes in HF patients elicits autonomic imbalance associated with parasympathetic withdrawal and increased adrenergic drive to the heart, thus fundamentally contributing to the evolution of the disease. Hence, on top of guideline-recommended medical therapy mainly based on neurohormonal antagonisms, all visceral feedbacks have been recently considered in HF patients as additional potential therapeutic targets.
Publish Date	2015-12-24 17:39
Citation	Giannoni A, Mirizzi G, Aimo A, Emdin M, Passino C. Peripheral reflex feedbacks in chronic heart failure: Is it time for a direct treatment? World J Cardiol 2015; 7(12): 824-828
URL	http://www.wjgnet.com/1949-8462/full/v7/i12/824.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i12.824

Full Article (PDF)	WJC-7-824.pdf
Full Article (Word)	WJC-7-824.doc
Manuscript File	21192-Review.docx
Answering Reviewers	21192-Answering reviewers.pdf
Audio Core Tip	21192-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	21192-Conflict-of-interest statement.pdf
Copyright License Agreement	21192-Copyright assignment.pdf
Peer-review Report	21192-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21192-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21192-Scientific misconduct check.pdf
Scientific Editor Work List	21192-Scientific editor work list.pdf