Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	21215
Country	Belgium

Received	2015-07-01 09:03
Peer-Review Started	2015-07-06 11:16
To Make the First Decision	2015-09-28 11:51
Return for Revision	2015-09-30 14:06
Revised	2015-12-02 00:00
Second Decision	2016-05-27 17:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-06-03 16:01
Articles in Press	2016-06-03 16:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-08-18 18:15
Publish the Manuscript Online	2016-08-25 09:10

ISSN	2220-3176 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Clinical research in febrile neutropenia in cancer patients: Past achievements and perspectives for the future
Manuscript Source	Invited Manuscript
All Author List	Jean Klastersky, Marianne Paesmans, Michel Aoun, Aspasia Georgala, Angela Loizidou, Yassine Lalami and Lissandra Dal Lago
Funding Agency and Grant Number
Corresponding Author	Jean Klastersky, MD, PhD, Institut Jules Bordet, Service de Médecine, Centre des Tumeurs de l’Université Libre de Bruxelles, 1, rue Héger-Bordet, 1000 Brussels, Belgium. jean.klastersky@bordet.be
Key Words	Fever; Neutropenia; Prophylaxis; Algorithm; Cancer
Core Tip	The overall presentation of febrile neutropenia has considerably changed over the last 50 years. Pre-vention is now feasible with the use of granulocyte colony stimulating factors. If fever appears in a neutro-penic patient, empirical therapy with broad spectrum antibiotics is mandatory; it should be adapted to the risk of severe complications that can be now predicted in individual patients using a reliable scoring system. Special situations such as persisting fever in neutropenic patients, the risk of invasive fungal infection and the management of older patients are crucial questions that are discussed as well as the issues linked to the high cost of prophylaxis and therapy.
Publish Date	2016-08-25 09:10
Citation	Klastersky J, Paesmans M, Aoun M, Georgala A, Loizidou A, Lalami Y, Dal Lago L. Clinical research in febrile neutropenia in cancer patients: Past achievements and perspectives for the future. World J Clin Infect Dis 2016; 6(3): 37-60
URL	http://www.wjgnet.com/2220-3176/full/v6/i3/37.htm
DOI	http://dx.doi.org/10.5495/wjcid.v6.i3.37

Full Article (PDF)	WJCID-6-37.pdf
Full Article (Word)	WJCID-6-37.doc
Manuscript File	21215-Review.docx
Answering Reviewers	21215-Answering reviewers.pdf
Audio Core Tip	21215-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21215-Conflict-of-interest statement.pdf
Copyright License Agreement	21215-Copyright assignment.pdf
Peer-review Report	21215-Peer-review(s).pdf
Scientific Misconduct Check	21215-Scientific misconduct check.pdf
Scientific Editor Work List	21215-Scientific editor work list.pdf