Publication Name	World Journal of Gastroenterology
Manuscript ID	21220
Country	Germany

Received	2015-07-01 08:48
Peer-Review Started	2015-07-04 22:09
To Make the First Decision	2015-09-29 12:45
Return for Revision	2015-10-09 15:35
Revised	2015-10-20 02:28
Second Decision	2015-12-22 12:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-30 17:27
Articles in Press	2015-12-30 17:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-28 16:17
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: A prospective study
Manuscript Source	Unsolicited Manuscript
All Author List	Anika Vogt, Philipp A Reuken, Sven Stengel, Andreas Stallmach and Tony Bruns
Funding Agency and Grant Number
Corresponding Author	Dr. Tony Bruns, MD, Department of Internal Medicine IV (Gastroenterology, Hepatology, and Infectious Diseases), Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany. tony.bruns@med.uni-jena.de
Key Words	Intestinal permeability; Liver cirrhosis; Lactulose/mannitol ratio; Spontaneous bacterial peritonitis; Bacterial translocation
Core Tip	Increased intestinal permeability (IP) is a frequent phenomenon in patients with cirrhosis and has been linked to pathological bacterial translocation, bacterial infections and mortality in retrospective studies. In this prospective study on 46 patients with cirrhosis we show that increased small-bowel IP, quantified using the lactulose/mannitol test, is frequently observed and correlates with inflammation and Child-Pugh stage. Although a higher IP index indicated an increased risk for developing spontaneous bacterial peritonitis, it failed to predict the pre-defined endpoints infection-free and overall survival. In contrast, the model for end-stage liver disease and Child-Pugh score, the presence of ascites, and higher serum levels of interleukin-6 or intestinal fatty-acid binding protein were significant univariate predictors of infection-free survival. Thus, the high prevalence of pathological test results in advanced cirrhosis and the lack of association with mortality limit the use of dual-sugar tests as tool for risk stratification in clinical practice.
Publish Date	2016-03-14 08:44
Citation	Vogt A, Reuken PA, Stengel S, Stallmach A, Bruns T. Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study. World J Gastroenterol 2016; 22(11): 3275-3284
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3275.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3275

Full Article (PDF)	WJG-22-3275.pdf
Full Article (Word)	WJG-22-3275.doc
Manuscript File	21220-Review.docx
Answering Reviewers	21220-Answering reviewers.pdf
Audio Core Tip	21220-Audio core tip.mp3
Biostatistics Review Certificate	21220-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21220-Conflict-of-interest statement.pdf
Copyright License Agreement	21220-Conflict-of-interest statement.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150701005433.pdf
Institutional Review Board Approval Form or Document	21220-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	21220-Language certificate.pdf
Peer-review Report	21220-Peer-review(s).pdf
Scientific Misconduct Check	21220-Scientific misconduct check.pdf
Scientific Editor Work List	21220-Scientific editor work list.pdf