Publication Name	World Journal of Hepatology
Manuscript ID	21223
Country	United States

Received	2015-07-01 08:34
Peer-Review Started	2015-07-04 22:33
To Make the First Decision	2015-08-31 16:36
Return for Revision	2015-09-01 11:48
Revised	2015-09-12 00:17
Second Decision	2015-12-23 16:36
Accepted by Journal Editor-in-Chief	2015-12-24 08:50
Accepted by Executive Editor-in-Chief	2016-01-07 16:34
Articles in Press	2016-01-07 16:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-10 18:01
Publish the Manuscript Online	2016-01-21 09:23

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Review
Article Title	Management of immunosuppressant agents following liver transplantation: Less is more
Manuscript Source	Invited Manuscript
All Author List	Mustafa S Ascha, Mona L Ascha and Ibrahim A Hanouneh
Funding Agency and Grant Number
Corresponding Author	Ibrahim A Hanouneh, MD, Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, United States. hanouni2@ccf.org
Key Words	Immunosuppression; Orthotopic liver transplantation; Metabolic syndrome; Acute cellular rejection; Hepatitis C virus
Core Tip	The use of immunosuppressive agents is reviewed in the context of the modern post-orthotopic liver transplantation population. The side effects of mainstay immunosuppressive strategies exacerbate some patient pathologies, and combinations of different immunosuppressants could be more specifically tailored to patient needs. Acute cellular rejection and malignant complications are also discussed with respect to im-munosuppressive strategies. Finally, hepatitis C virus and its impact on immunosuppression is re-evaluated in light of recent developments in viral clearance.
Publish Date	2016-01-21 09:23
Citation	Ascha MS, Ascha ML, Hanouneh IA. Management of immuno­suppressant agents following liver transplantation: Less is more. World J Hepatol 2016; 8(3): 148-161
URL	http://www.wjgnet.com/1948-5182/full/v8/i3/148.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i3.148

Full Article (PDF)	WJH-8-148.pdf
Full Article (Word)	WJH-8-148.doc
Manuscript File	21223-Review.docx
Answering Reviewers	21223-Answering reviewers.pdf
Audio Core Tip	21223-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21223-Conflict-of-interest statement.pdf
Copyright License Agreement	21223-Copyright assignment.pdf
Peer-review Report	21223-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21223-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21223-Scientific misconduct check.pdf
Scientific Editor Work List	21223-Scientific editor work list.pdf