Publication Name	World Journal of Clinical Oncology
Manuscript ID	21247
Country	United States

Received	2015-07-02 08:46
Peer-Review Started	2015-07-07 13:26
First Decision by Editorial Office Director
Return for Revision	2015-09-18 17:45
Revised	2016-01-05 17:04
Publication Fee Transferred
Second Decision by Editor	2016-01-25 14:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-02-16 09:49
Articles in Press	2016-02-16 09:49
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-25 17:59
Publish the Manuscript Online	2016-04-07 11:01

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Estrogen receptor alpha gene amplification in breast cancer: 25 years of debate
Manuscript Source	Invited Manuscript
All Author List	Frederik Holst
Funding Agency and Grant Number
Corresponding Author	Frederik Holst, PhD, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, 450 Brookline Avenue, Boston, MA 02215, United States. frederik.holst@uib.no
Key Words	Estrogen receptor alpha gene; Breast cancer; Tamoxifen; Gene amplification; Methodology
Core Tip	The estrogen receptor alpha gene gene (ESR1) is one of the most important genes in breast cancer, but the prevalence of ESR1 amplification is matter of ongoing debate. A number of studies suggest that technical issues and lack of standards contribute to the discrepant findings. Future studies should focus on the potential clinical relevance of this phenomenon.
Publish Date	2016-04-07 11:01
Citation	Holst F. Estrogen receptor alpha gene amplification in breast cancer: 25 years of debate. World J Clin Oncol 2016; 7(2): 160-173
URL	http://www.wjgnet.com/2218-4333/full/v7/i2/160.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i2.160

Full Article (PDF)	WJCO-7-160.pdf
Full Article (Word)	WJCO-7-160.doc
Manuscript File	21247-Review.docx
Answering Reviewers	21247-Answering reviewers.pdf
Audio Core Tip	21247-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21247-Conflict-of-interest statement.pdf
Copyright License Agreement	21247-Copyright assignment.pdf
Supplementary Material	21247-Supplementary material.pdf
Peer-review Report	21247-Peer-review(s).pdf
Scientific Misconduct Check	21247-Scientific misconduct check.pdf
Scientific Editor Work List	21247-Scientific editor work list.pdf