Publication Name	World Journal of Immunology
Manuscript ID	21402
Country	France

Received	2015-07-09 16:45
Peer-Review Started	2015-07-14 12:05
To Make the First Decision	2015-07-27 15:57
Return for Revision	2015-07-31 17:46
Revised	2015-08-27 05:42
Second Decision	2015-10-14 08:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-10-27 18:39
Articles in Press	2015-10-27 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-06 14:23
Publish the Manuscript Online	2015-11-27 16:41

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Review
Article Title	Macrophage populations and self-renewal: Changing the paradigm
Manuscript Source	Invited Manuscript
All Author List	Rym Belhareth and Jean-Louis Mège
Funding Agency and Grant Number
Corresponding Author	Jean-Louis Mège, MD, PhD, URMITE, Faculté de Médecine, 27 Bld. Jean Moulin, 13005 Marseille, France. jean-louis.mege@univ-amu.fr
Key Words	Macrophages; Self-renewal; Proliferation; Homeostasis; Diseases
Core Tip	The emergence of revolutionary technologies in myeloid cell research has deeply changed the paradigm of macrophage activation. It was believed that macrophage derive from myeloid precursors via circulating monocytes. Now, we can propose that resident macrophages are of embryonic origin in steady state whereas monocytes are recruited in pathological conditions. The second strong idea was that mature macrophages are unable to proliferate; we have strong evidence that macrophages can proliferate, which is the basis of self-renewal. The consequences of these new concepts will lead us to reappraise the role of macrophages in pathologies.
Publish Date	2015-11-27 16:41
Citation	Belhareth R, Mège JL. Macrophage populations and self-renewal: Changing the paradigm. World J Immunol 2015; 5(3): 131-141
URL	http://www.wjgnet.com/2219-2824/full/v5/i3/131.htm
DOI	http://dx.doi.org/10.5411/wji.v5.i3.131

Full Article (PDF)	WJI-5-131.pdf
Full Article (Word)	WJI-5-131.doc
Manuscript File	21402-Review.docx
Answering Reviewers	21402-Answering reviewers.pdf
Audio Core Tip	21402-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21402-Conflict-of-interest statement.pdf
Copyright License Agreement	21402-Copyright assignment.pdf
Peer-review Report	21402-Peer-review(s).pdf
Scientific Misconduct Check	21402-Scientific misconduct check.pdf
Scientific Editor Work List	21402-Scientific editor work list.pdf