Publication Name	World Journal of Immunology
Manuscript ID	21656
Country	United Kingdom

Received	2015-07-24 09:26
Peer-Review Started	2015-07-27 15:18
To Make the First Decision	2015-08-16 14:56
Return for Revision	2015-08-25 19:32
Revised	2015-09-18 23:44
Second Decision	2015-11-02 14:24
Accepted by Journal Editor-in-Chief	2015-11-05 07:36
Accepted by Executive Editor-in-Chief	2015-11-11 18:11
Articles in Press	2015-11-11 18:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-16 09:02
Publish the Manuscript Online	2015-11-27 16:41

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Review
Article Title	Dendritic cells and the extracellular matrix: A challenge for maintaining tolerance/homeostasis
Manuscript Source	Invited Manuscript
All Author List	Sucharita P Shankar, May Griffith, John V Forrester and Lucia Kuffová
Funding Agency and Grant Number
Corresponding Author	Dr. Lucia Kuffová, MD, PhD, Section of Immunology, Inflammation and Infection, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland AB25 2ZD, United Kingdom. l.kuffova@abdn.ac.uk
Key Words	Dendritic cells; Extracellular matrix; Tolerance; Biomaterials; Homeostasis; Regenerative medicine; Biointeractive implants
Core Tip	The extracellular matrix (ECM) provides an essential framework for tissues in the body as well as actively orchestrates diverse cellular functions. Professional antigen presenting cells namely dendritic cells (DCs) are uniquely positioned to distinguish between self and non-self and accordingly regulate systemic immunity or tolerance. DCs and the ECM participate in finely-tuned, dynamic exchanges that ultimately impact the equilibrium between steady-state DC tissue residence or DC-instigated inflammation. To design biointeractive, ECM-inspired implants for regenerative medicine applications that retain functionality and undergo successful integration long-term, it is critical to understand the challenges involved in maintaining DC-ECM immune homeostasis under normal conditions.
Publish Date	2015-11-27 16:41
Citation	Shankar SP, Griffith M, Forrester JV, Kuffová L. Dendritic cells and the extracellular matrix: A challenge for maintaining tolerance/homeostasis. World J Immunol 2015; 5(3): 113-130
URL	http://www.wjgnet.com/2219-2824/full/v5/i3/113.htm
DOI	http://dx.doi.org/10.5411/wji.v5.i3.113

Full Article (PDF)	WJI-5-113.pdf
Full Article (Word)	WJI-5-113.doc
Manuscript File	21656-Review.docx
Answering Reviewers	21656-Answering reviewers.pdf
Audio Core Tip	21656-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21656-Conflict-of-interest statement.pdf
Copyright License Agreement	21656-Copyright assignment.pdf
Peer-review Report	21656-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21656-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21656-Scientific misconduct check.pdf
Scientific Editor Work List	21656-Scientific editor work list.pdf