Publication Name	World Journal of Transplantation
Manuscript ID	21665
Country	United States

Received	2015-07-24 08:19
Peer-Review Started	2015-07-27 11:16
To Make the First Decision	2015-09-16 09:15
Return for Revision	2015-09-22 18:30
Revised	2015-10-23 04:00
Second Decision	2015-11-12 14:14
Accepted by Journal Editor-in-Chief	2015-11-15 01:43
Accepted by Executive Editor-in-Chief	2015-11-25 17:28
Articles in Press	2015-11-25 17:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-16 09:13
Publish the Manuscript Online	2015-12-23 08:25

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Transplantation
Manuscript Type	Minireviews
Article Title	Use of genetically-engineered pig donors in islet transplantation
Manuscript Source	Invited Manuscript
All Author List	Rita Bottino and Massimo Trucco
Funding Agency and Grant Number
Corresponding Author	Dr. Rita Bottino, Institute of Cellular Therapeutics, Allegheny-Singer Research Institute, Allegheny Health Network, 320 East North Avenue, Pittsburgh, PA 15212-4772, United States. rbottino@wpahs.org
Key Words	Genetic-engineering; Diabetes; Pig; Islets; Xenotransplantation
Core Tip	Type 1 diabetes is widespread and debilitating. Islet allotransplantation from deceased human donors can reverse diabetes but there are too few donors to provide much help for more than a few recipients. Xenotransplantation of pig islets, readily obtainable in large quantities, can bridge this gap. Genetic mani-pulation of pigs in order to render their tissue more compatible with human recipients can improve graft function and would be necessary for clinical trials. Experience within the pig-to-nonhuman primate model help to determine the most beneficial enhancements, while technology evolves to provide improved tech-niques for multiple genetic manipulations.
Publish Date	2015-12-23 08:25
Citation	Bottino R, Trucco M. Use of genetically-engineered pig donors in islet transplantation. World J Transplant 2015; 5(4): 243-250
URL	http://www.wjgnet.com/2220-3230/full/v5/i4/243.htm
DOI	http://dx.doi.org/10.5500/wjt.v5.i4.243

Full Article (PDF)	WJT-5-243.pdf
Full Article (Word)	WJT-5-243.doc
Manuscript File	21665-Review.docx
Answering Reviewers	21665-Answering reviewers.pdf
Audio Core Tip	21665-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21665-Conflict-of-interest statement.PDF
Copyright License Agreement	21665-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21665-Language certificate.PDF
Peer-review Report	21665-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21665-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21665-Scientific misconduct check.pdf
Scientific Editor Work List	21665-Scientific editor work list.pdf