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Publication Name World Journal of Radiology
Manuscript ID 21684
Country United States
Received
2015-07-30 16:06
Peer-Review Started
2015-08-04 08:31
To Make the First Decision
2015-09-28 13:35
Return for Revision
2015-10-10 15:46
Revised
2015-11-03 22:43
Second Decision
2016-03-07 15:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-03-18 16:14
Articles in Press
2016-03-18 16:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-06-01 14:13
Publish the Manuscript Online
2016-06-18 17:56
ISSN 1949-8470 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neuroimaging
Manuscript Type Basic Study
Article Title Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy
Manuscript Source Invited Manuscript
All Author List Humberto Morales, Lisa Lemen, Ranasinghage Samaratunga, Peter Nguyen and Thomas Tomsick
Funding Agency and Grant Number
Funding Agency Grant Number
2008 Neuroradiology Education and Research Fund of the American Society of Neuroradiology partially via the Boston Scientific Fellowship in Cerebrovascular Disease Research Award to Humberto Morales MD, Principal Investigator
Corresponding Author Humberto Morales, MD, Assistant Professor of Radiology Section of Neuroradiology, Department of Radiology, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH 45267-0761, United States. moralehc@ucmail.uc.edu
Key Words Iodinated contrast; Magnetic resonance imaging; Gradient-echo; Hemorrhage; Stroke
Core Tip After recent groundbreaking stroke clinical trials have shown positive outcomes with endovascular therapy, the use of imaging, particularly magnetic resonance imaging (MRI) is expected to increase in this setting. Iodinated contrast material (ICM) is inherent to this scenario and can be deposited in the brain after intra-arterial or intra-venous injection. Differentiation of ICM from hemorrhagic changes is of upmost clinical importance. This paper demonstrates the signal chara-cteristics of in vitro ICM with routine MR sequences [including not previously reported changes on gradient-echo (GRE)]. Changes at high magnetic field (3T) are to the best of our knowledge described for the first time, with T2 hypo intensity as the signal change with greatest conspicuity as compared with other routine brain sequences. Furthermore, no significant conspicuity/hypo intensity on GRE is demonstrate and postulated as a way to differentiate contrast deposition (T2 hypo intensity or T1 hyper intensity) from hemo-rrhagic changes.
Publish Date 2016-06-18 17:56
Citation Morales H, Lemen L, Samaratunga R, Nguyen P, Tomsick T. Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy. World J Radiol 2016; 8(6): 588-593
URL http://www.wjgnet.com/1949-8470/full/v8/i6/588.htm
DOI http://dx.doi.org/10.4329/wjr.v8.i6.588
Full Article (PDF) WJR-8-588.pdf
Full Article (Word) WJR-8-588.doc
Manuscript File 21684-Review.docx
Answering Reviewers 21684-Answering reviewers.pdf
Audio Core Tip 21684-Audio core tip.mp3
Biostatistics Review Certificate 21684-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21684-Conflict-of-interest statement.pdf
Copyright License Agreement 21684-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 21684-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150730030307.docx
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20150730030316.docx
Institutional Review Board Approval Form or Document 21684-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate Editing_Certificate_20150730030247.docx
Supplementary Material Supplementary_Material_20150730030418.docx
Peer-review Report 21684-Peer-review(s).pdf
Scientific Misconduct Check 21684-Scientific misconduct check.pdf
Scientific Editor Work List 21684-Scientific editor work list.pdf