Publication Name	World Journal of Cardiology
Manuscript ID	21701
Country	Italy

Received	2015-07-26 12:16
Peer-Review Started	2015-07-27 09:10
To Make the First Decision	2015-09-16 09:15
Return for Revision	2015-09-22 18:54
Revised	2015-10-06 02:44
Second Decision	2015-11-27 15:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-08 15:21
Articles in Press	2015-12-08 15:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-03 09:52
Publish the Manuscript Online	2016-02-22 10:45

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Mechanical dyssynchrony and deformation imaging in patients with functional mitral regurgitation
Manuscript Source	Invited Manuscript
All Author List	Isabella Rosa, Claudia Marini, Stefano Stella, Francesco Ancona, Marco Spartera, Alberto Margonato and Eustachio Agricola
Funding Agency and Grant Number
Corresponding Author	Claudia Marini, MD, Echocardiography Laboratory, San Raffaele Hospital, IRCCS, Via Olgettina 60, 20132 Milano, Italy. claudia.marini@outlook.com
Key Words	Mitral regurgitation; Deformation imaging; 3D echocardiography; Mechanical dyssynchrony; Speckle tracking
Core Tip	The epidemiologic and prognostic impact of chronic functional mitral regurgitation (FMR) is fully acknowledged. Multiple factors are involved in the pathophysiology of FMR, such as mitral valve remodeling, left ventricle (LV) remodeling and mechanical dyssynchrony. Deformation imaging by 2 dimensional speckle tracking and 3 dimensional echocardiography are the echocardiographic techniques currently used to better characterize LV dyssynchrony. Pharmacologic and cardiac resynchronization therapy is the first line-therapeutic approach to treat FMR. In case of failure of this first therapeutic approach, surgery and percutaneous treatment in high risk patients represent an alternative option.
Publish Date	2016-02-22 10:45
Citation	Rosa I, Marini C, Stella S, Ancona F, Spartera M, Margonato A, Agricola E. Mechanical dyssynchrony and deformation imaging in patients with functional mitral regurgitation. World J Cardiol 2016; 8(2): 146-162
URL	http://www.wjgnet.com/1949-8462/full/v8/i2/146.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i2.146

Full Article (PDF)	WJC-8-146.pdf
Full Article (Word)	WJC-8-146.doc
Manuscript File	21701-Review.docx
Answering Reviewers	21701-Answering reviewers.pdf
Audio Core Tip	21701-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21701-Conflict-of-interest statement.pdf
Copyright License Agreement	21701-Copyright assignment.pdf
Peer-review Report	21701-Peer-review(s).pdf
Scientific Misconduct Check	21701-Scientific misconduct check.pdf
Scientific Editor Work List	21701-Scientific editor work list.pdf