Publication Name	World Journal of Critical Care Medicine
Manuscript ID	21826
Country	United States

Received	2015-07-29 08:29
Peer-Review Started	2015-07-29 16:44
To Make the First Decision	2015-10-08 16:54
Return for Revision	2015-10-13 17:19
Revised	2015-10-19 09:14
Second Decision	2015-11-12 14:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-25 17:32
Articles in Press	2015-11-25 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-15 08:30
Publish the Manuscript Online

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Review
Article Title	Antithrombin in the treatment of burn trauma
Manuscript Source	Invited Manuscript
All Author List	Areta Kowal-Vern and Bruce A Orkin
Funding Agency and Grant Number
Corresponding Author	Areta Kowal-Vern, MD, FCAP, FASCP, CTBS, Assistant Professor, Department of General Surgery, Rush University Medical Center, Professional Building, Suite 1138, 1725 Harrison Street, Chicago, IL 60612, United States. akvern@comcast.net
Key Words	Antithrombin; Burn trauma; Burn injury; Inhalation injury; Recombinant antithrombin
Core Tip	Based on ovine and rat research, and civilian population studies, antithrombin (AT) therapy with either human plasma-derived AT or recombinant AT (rhAT) may be a valuable adjunct treatment in patients with ≥ 25% total body surface area burn. AT has anticoagulant and anti-inflammatory properties, a positive effect on cardiopulmonary function, and wound healing, with concomitant decreases in pneumonia and mortality. Studies in human volunteers with endotoxemia have shown that rhAT doses as high as 200% and 500% are tolerated safely. With adequate high doses, AT may decrease blood loss during eschar excision, and reduce blood transfusion requirements.
Publish Date
Citation	Kowal-Vern A, Orkin BA. Antithrombin in the treatment of burn trauma. World J Crit Care Med 2016; 5(1): 17-26
URL	http://www.wjgnet.com/2220-3141/full/v5/i1/17.htm
DOI	http://dx.doi.org/10.5492/wjccm.v5.i1.17

Full Article (PDF)	WJCCM-5-17.pdf
Full Article (Word)	WJCCM-5-17.doc
Manuscript File	21826-Review.docx
Answering Reviewers	21826-Answering reviewers.pdf
Audio Core Tip	21826-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21826-Conflict-of-interest statement.pdf
Copyright License Agreement	21826-Copyright assignment.pdf
Peer-review Report	21826-Peer-review(s).pdf
Scientific Misconduct Check	21826-Scientific misconduct check.pdf
Scientific Editor Work List	21826-Scientific editor work list.pdf