Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	21828
Country	United Kingdom

Received	2015-07-29 08:25
Peer-Review Started	2015-07-31 10:34
To Make the First Decision	2015-12-04 11:10
Return for Revision	2015-12-07 16:28
Revised	2015-12-17 00:14
Second Decision	2016-01-12 16:14
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-19 10:32
Articles in Press	2016-01-19 10:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-08 10:38
Publish the Manuscript Online	2016-05-02 18:55

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence
Manuscript Source	Invited Manuscript
All Author List	Sadaf I Bhayat, Harsha MS Gowda and Michael Eisenhut
Funding Agency and Grant Number
Corresponding Author	Sadaf I Bhayat, MD, Neonatal and Paediatric Department, Luton and Dunstable NHS Foundation Trust, Lewsey Rd, Luton LU4 0DZ, United Kingdom. sadafbhayat@gmail.com
Key Words	Hypotension; Preterm; Inotrope; Dopamine; Dobutamine; Adrenaline/epinephrine; Corticosteroids
Core Tip	Hypotension is a common feature in the preterm infant. The aim of this systematic review was to determine, after review of evidence, if dopamine would make a good first line drug therapy for hypo-tension in the neonatal population. Dopamine was shown across trials to increase blood pressure more effectively than dobutamine. There was no difference in morbidity and mortality outcomes when dopamine was compared to hydrocortisone or adrenaline. In preterm infants, dopamine is the most studied drug, and in general safer than others to use, we therefore cautiously suggest it could be used as first line treatment in hypotension.
Publish Date	2016-05-02 18:55
Citation	Bhayat SI, Gowda HMS, Eisenhut M. Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence. World J Clin Pediatr 2016; 5(2): 212-222
URL	http://www.wjgnet.com/2219-2808/full/v5/i2/212.htm
DOI	http://dx.doi.org/10.5409/wjcp.v5.i2.212

Full Article (PDF)	WJCP-5-212.pdf
Full Article (Word)	WJCP-5-212.doc
Manuscript File	21828-Review.docx
Answering Reviewers	21828-Answering reviewers.pdf
Audio Core Tip	21828-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21828-Conflict-of-interest statement.pdf
Copyright License Agreement	21828-Copyright assignment.pdf
Peer-review Report	21828-Peer-review(s).pdf
Scientific Misconduct Check	21828-Scientific misconduct check.pdf
Scientific Editor Work List	21828-Scientific editor work list.pdf