Publication Name	World Journal of Cardiology
Manuscript ID	21861
Country	Italy

Received	2015-07-31 08:50
Peer-Review Started	2015-07-31 14:08
To Make the First Decision	2015-09-16 09:00
Return for Revision	2015-09-28 11:47
Revised	2015-09-28 21:19
Second Decision	2015-12-11 12:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-18 17:16
Articles in Press	2015-12-18 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-01-02 03:43
Typeset the Manuscript	2016-02-03 09:49
Publish the Manuscript Online	2016-02-22 10:45

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Novel epigenetic-based therapies useful in cardiovascular medicine
Manuscript Source	Invited Manuscript
All Author List	Claudio Napoli, Vincenzo Grimaldi, Maria Rosaria De Pascale, Linda Sommese, Teresa Infante and Andrea Soricelli
Funding Agency and Grant Number
Corresponding Author	Vincenzo Grimaldi, MB, BiolD, Division of Immunohematology, Transfusion Medicine and Transplant Immunology, Department of Internal Medicine and Specialistic Unit, Azienda Ospedaliera Universitaria (AOU), Second University of Naples, Piazza L. Miraglia 2, 80138 Naples, Italy. vincenzo.grimaldi@policliniconapoli.it
Key Words	Epigenetics; Cardiovascular diseases; Heart failure; Inhibitors of histone deacetylases; Antisense microRNAs
Core Tip	Recent evidence suggests that specific epigenetic regulatory mechanisms play key roles in cardiac differe?ntiation, homeostasis, injury response, and disease development. Drug therapies that work via epigenetic mechanisms are currently limited to antineoplastic agents; large controlled trials are required to establish whether current possible candidate antisense microRNAs or histone deacetylase inhibitors could offer better therapeutic benefits in cardiovascular disease. We review recent findings on the epigenetic control of several cardiovascular diseases and the new challenges for therapeutic strategies in cardiovascular diseases.
Publish Date	2016-02-22 10:45
Citation	Napoli C, Grimaldi V, De Pascale MR, Sommese L, Infante T, Soricelli A. Novel epigenetic-based therapies useful in cardiovascular medicine. World J Cardiol 2016; 8(2): 211-219
URL	http://www.wjgnet.com/1949-8462/full/v8/i2/211.htm
DOI	http://dx.doi.org/10.4330/wjc.v8.i2.211

Full Article (PDF)	WJC-8-211.pdf
Full Article (Word)	WJC-8-211.doc
Manuscript File	21861-Review.docx
Answering Reviewers	21861-Answering reviewers.pdf
Audio Core Tip	21861-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21861-Conflict-of-interest statement.pdf
Copyright License Agreement	21861-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150730184908.pdf
Peer-review Report	21861-Peer-review(s).pdf
Scientific Misconduct Check	21861-Scientific misconduct check.pdf
Scientific Editor Work List	21861-Scientific editor work list.pdf