Publication Name	World Journal of Hepatology
Manuscript ID	21878
Country	Australia

Received	2015-08-07 08:23
Peer-Review Started	2015-08-10 18:48
To Make the First Decision	2015-09-16 13:57
Return for Revision	2015-09-21 18:32
Revised	2015-12-23 09:19
Second Decision	2016-02-16 10:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-09 12:37
Articles in Press	2016-03-09 12:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-10 11:52
Publish the Manuscript Online	2016-03-15 11:19

ISSN	1948-5182 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Management of human factors engineering-associated hemochromatosis: A 2015 update
Manuscript Source	Invited Manuscript
All Author List	Menaka Sivakumar and Lawrie W Powell
Funding Agency and Grant Number
Corresponding Author	Lawrie W Powell, MD, PhD, Director, Professor, Centre for the Advancement of Clinical Research, Royal Brisbane and Women’s Hospital Campus, Level 4, UQ Centre for Clinical Research, Building 71/918, Brisbane QLD 4029, Australia. lawrie.powell@qimrberghofer.edu.au
Key Words	Human factors engineering; Iron storage diseases; Genetics; Venesections; Hemochromatosis
Core Tip	The concept of hemochromatosis as a single disease entity has changed to an iron storage disease resulting from several genetic disorders although the final common metabolic pathway is inappropriate iron absorption from the intestine and progressive tissue iron loading. The most common form of the disease is due to a mutation in the human factors engineering gene resulting in cysteine tyrosine substitution at position 282 in the molecule. This mutation is relatively common in populations of northern European extraction but is rare in other populations. In contrast other rarer forms of hemochromatosis resulting from other mutations in the hepcidin pathway are quite ubiquitous. The main stay of treatment remains venesection although new oral iron-chelating agents show promise.
Publish Date	2016-03-15 11:19
Citation	Sivakumar M, Powell LW. Management of human factors engineering-associated hemochromatosis: A 2015 update. World J Hepatol 2016; 8(8): 395-400
URL	http://www.wjgnet.com/1948-5182/full/v8/i8/395.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i8.395

Full Article (PDF)	WJH-8-395.pdf
Full Article (Word)	WJH-8-395.doc
Manuscript File	21878-Review.docx
Answering Reviewers	21878-Answering reviewers.pdf
Audio Core Tip	21878-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21878-Conflict-of-interest statement.pdf
Copyright License Agreement	21878-Copyright assignment.pdf
Peer-review Report	21878-Peer-review(s).pdf
Scientific Misconduct Check	21878-Scientific misconduct check.pdf
Scientific Editor Work List	21878-Scientific editor work list.pdf