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1/26/2016 6:22:00 PM | Browse: 699 | Download: 850
Publication Name World Journal of Hepatology
Manuscript ID 21933
Country of Manuscript Source United States
Received
2015-08-03 08:44
Peer-Review Started
2015-08-03 14:06
To Make the First Decision
2015-09-29 14:29
Return for Revision
2015-09-30 10:17
Revised
2015-10-14 00:45
Second Decision
2015-11-03 09:15
Accepted by Journal Editor-in-Chief
2015-11-04 09:46
Accepted by Company Editor-in-Chief
2015-11-13 16:05
Articles in Press
2015-11-13 16:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-12 11:41
Publish the Manuscript Online
2016-01-26 18:22
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Basic Study
Article Title Lack of hepcidin expression attenuates steatosis and causes fibrosis in the liver
Manuscript Source Unsolicited Manuscript
All Author List Sizhao Lu, Robert G Bennett, Kusum K Kharbanda and Duygu Dee Harrison-Findik
Funding Agency and Grant Number
Funding Agency Grant Number
NIH R01AA017738 (to Harrison-Findik DD)
University of Nebraska Medical Center Graduate Assistantship/Fellowship to Lu S
Corresponding author Duygu Dee Harrison-Findik, DVM, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 92000 UNMC, Omaha, NE 68198-2000, United States. dufindik@gmail.com
Keywords Hamp; Iron; Non-alcoholic steatohepatitis; Metabolic genes; Steatosis; non-alcoholic fatty liver disease; Steatohepatitis
Core Tip Due to obesity epidemic the incidence of non-alcoholic fatty liver disease (NAFLD) is on the rise. Iron contributes to disease severity and the expression of key iron regulatory hormone, hepcidin is modulated in NAFLD patients. The underlying mechanisms are unknown. We have generated hepcidin knockout mice with iron overload phenotype. This study investigates the role of hepcidin in NAFLD by using high fat and high sucrose-fed knockout mice as an experimental model of NAFLD. Our findings showed attenuated steatosis and early fibrosis development suggesting a role for hepcidin in the regulation of metabolic processes in the liver, and in NAFLD.
Publish Date 2016-01-26 18:22
Citation Lu S, Bennett RG, Kharbanda KK, Harrison-Findik DD. Lack of hepcidin expression attenuates steatosis and causes fibrosis in the liver. World J Hepatol 2016; 8(4): 211-225
Url http://www.wjgnet.com/1948-5182/full/v8/i4/211.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i4.211
Full Article (PDF) WJH-8-211.pdf
Full Article (Word) WJH-8-211.doc
Manuscript File 21933-Review.docx
Answering Reviewers 21933-Answering reviewers.pdf
Audio Core Tip 21933-Audio core tip.mp3
Biostatistics Review Certificate 21933-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21933-Conflict-of-interest statement.pdf
Copyright License Agreement 21933-Copyright assignment.pdf
Data Sharing Statement 21933-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 21933-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 21933-Institutional review board statement.pdf
Peer-review Report 21933-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21933-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21933-Scientific misconduct check.pdf
Scientific Editor Work List 21933-Scientific editor work list.pdf