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Articles Published Processes
1/26/2016 6:22:00 PM | Browse: 1498 | Download: 2408
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Received |
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2015-08-03 08:44 |
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Peer-Review Started |
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2015-08-03 14:06 |
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To Make the First Decision |
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2015-09-29 14:29 |
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Return for Revision |
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2015-09-30 10:17 |
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Revised |
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2015-10-14 00:45 |
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Second Decision |
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2015-11-03 09:15 |
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Accepted by Journal Editor-in-Chief |
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2015-11-04 09:46 |
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Accepted by Executive Editor-in-Chief |
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2015-11-13 16:05 |
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Articles in Press |
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2015-11-13 16:05 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-12 11:41 |
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Publish the Manuscript Online |
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2016-01-26 18:22 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Lack of hepcidin expression attenuates steatosis and causes fibrosis in the liver
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sizhao Lu, Robert G Bennett, Kusum K Kharbanda and Duygu Dee Harrison-Findik |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH |
R01AA017738 (to Harrison-Findik DD) |
| University of Nebraska Medical Center Graduate Assistantship/Fellowship |
to Lu S |
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| Corresponding Author |
Duygu Dee Harrison-Findik, DVM, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, 92000 UNMC, Omaha, NE 68198-2000,
United States. dufindik@gmail.com
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| Key Words |
Hamp; Iron; Non-alcoholic steatohepatitis; Metabolic genes; Steatosis; non-alcoholic fatty liver disease; Steatohepatitis |
| Core Tip |
Due to obesity epidemic the incidence of non-alcoholic fatty liver disease (NAFLD) is on the rise. Iron contributes to disease severity and the expression of key iron regulatory hormone, hepcidin is modulated in NAFLD patients. The underlying mechanisms are unknown. We have generated hepcidin knockout mice with iron overload phenotype. This study investigates the role of hepcidin in NAFLD by using high fat and high sucrose-fed knockout mice as an experimental model of NAFLD. Our findings showed attenuated steatosis and early fibrosis development suggesting a role for hepcidin in the regulation of metabolic processes in the liver, and in NAFLD.
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| Publish Date |
2016-01-26 18:22 |
| Citation |
Lu S, Bennett RG, Kharbanda KK, Harrison-Findik DD. Lack of hepcidin expression attenuates steatosis and causes fibrosis in the liver. World J Hepatol 2016; 8(4): 211-225 |
| URL |
http://www.wjgnet.com/1948-5182/full/v8/i4/211.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v8.i4.211 |
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