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Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 21992
Country/Territory Bangladesh
2015-08-31 08:59
Peer-Review Started
2015-09-05 21:43
To Make the First Decision
2015-11-24 14:53
Return for Revision
2015-11-30 14:27
2016-01-03 12:32
Second Decision
2016-02-18 11:57
Accepted by Journal Editor-in-Chief
2016-02-19 00:51
Accepted by Company Editor-in-Chief
2016-03-09 12:38
Articles in Press
2016-03-09 12:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-04-20 18:02
Publish the Manuscript Online
2016-05-12 16:59
ISSN 2150-5330 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Insulin resistance in development and progression of nonalcoholic fatty liver disease
Manuscript Source Invited Manuscript
All Author List Shahinul Alam, Golam Mustafa, Mahabubul Alam and Nooruddin Ahmad
Funding Agency and Grant Number
Corresponding author Shahinul Alam, Associate Professor, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh. shahinul67@yahoo.com
Keywords Nonalcoholic fatty liver disease; Insulin resistance; Metabolic syndrome; Diabetes; Nonalcoholic steatohepatitis
Core Tip Insulin resistance is considered as the major contributor for the development and progression of nonalcoholic fatty liver disease (NAFLD). However, recent evidence that has shown that non-obese indivi-duals from developing countries are also affected by NAFLD, thus the conventional paradigm of NAFLD as the “hepatic manifestation of metabolic syndrome” has become outdated. Recent studies have highlighted novel pathophysiological mechanisms for the develop-ment and progression of NAFLD. Insulin resistance contributes to the disease process, but it is evident that environmental and genetic factors also contribute for development of necroinflammation and subsequent progression to fibrosis. This review provides a summary of current knowledge of the pathogenesis of NAFLD and discusses factors that dissociate insulin resistance from NAFLD.
Publish Date 2016-05-12 16:59
Citation Alam S, Mustafa G, Alam M, Ahmad N. Insulin resistance in development and progression of nonalcoholic fatty liver disease. World J Gastrointest Pathophysiol 2016; 7(2): 211-217
Url http://www.wjgnet.com/2150-5330/full/v7/i2/211.htm
DOI http://dx.doi.org/10.4291/wjgp.v7.i2.211
Full Article (PDF) WJGP-7-211.pdf
Full Article (Word) WJGP-7-211.doc
Manuscript File 21992-Review.docx
Answering Reviewers 21992-Answering reviewers.pdf
Audio Core Tip 21992-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21992-Conflict-of-interest statement.pdf
Copyright License Agreement 21992-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21992-Language certificate.pdf
Peer-review Report 21992-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21992-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21992-Scientific misconduct check.pdf
Scientific Editor Work List 21992-Scientific editor work list.pdf