Publication Name	World Journal of Critical Care Medicine
Manuscript ID	22031
Country	Greece

Received	2015-08-07 08:39
Peer-Review Started	2015-08-10 17:49
To Make the First Decision	2015-09-16 13:59
Return for Revision	2015-09-22 10:25
Revised	2015-10-08 22:19
Second Decision	2015-11-30 09:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-11 16:45
Articles in Press	2015-12-11 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-15 08:29
Publish the Manuscript Online

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Respiratory mechanics in brain injury: A review
Manuscript Source	Invited Manuscript
All Author List	Antonia Koutsoukou, Maria Katsiari, Stylianos E Orfanos, Anastasia Kotanidou, Maria Daganou, Magdalini Kyriakopoulou, Nikolaos G Koulouris and Nikoletta Rovina
Funding Agency and Grant Number
Corresponding Author	Antonia Koutsoukou, Associate Professor, ICU, First Department of Respiratory medicine, University of Athens Medical School, Sotiria Hospital, Mesogion Av 152, 11527 Athens, Greece. koutsoukou@yahoo.gr
Key Words	Brain damage; Respiratory mechanics; Positive end-expiratory pressure; Lung injury; Ventilator-induced lung injury
Core Tip	Clinical and experimental evidence supports that preclinical lung injury occurs shortly after brain damage. Brain-damaged patients exhibit altered respiratory system mechanics and hypoxemia, even in the absence of clinically evident lung injury. Measurement of respiratory mechanics in such patients may reveal brain damage related lung injury early enough, and facilitate selection of the appropriate ventilator settings to avoid ventilator induced lung injury. Lung protective ventilation, consisting of low tidal volume and moderate levels of positive end-expiratory pressure, may prevent a further deterioration of respiratory dysfunction, and could be possibly associated with improved outcome.
Publish Date
Citation	Koutsoukou A, Katsiari M, Orfanos SE, Kotanidou A, Daganou M, Kyriakopoulou M, Koulouris NG, Rovina N. Respiratory mechanics in brain injury: A review. World J Crit Care Med 2016; 5(1): 65-73
URL	http://www.wjgnet.com/2220-3141/full/v5/i1/65.htm
DOI	http://dx.doi.org/10.5492/wjccm.v5.i1.65

Full Article (PDF)	WJCCM-5-65.pdf
Full Article (Word)	WJCCM-5-65.doc
Manuscript File	22031-Review.doc
Answering Reviewers	22031-Answering reviewers.pdf
Audio Core Tip	22031-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22031-Conflict-of-interest statement.pdf
Copyright License Agreement	22031-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22031-Language certificate.pdf
Peer-review Report	22031-Peer-review(s).pdf
Scientific Misconduct Check	22031-Scientific misconduct check.pdf
Scientific Editor Work List	22031-Scientific editor work list.pdf