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12/24/2015 11:11:00 AM | Browse: 1107 | Download: 1797
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Received |
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2015-08-10 19:07 |
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Peer-Review Started |
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2015-08-11 08:15 |
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To Make the First Decision |
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2015-10-14 18:00 |
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Return for Revision |
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2015-10-15 13:50 |
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Revised |
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2015-10-22 02:27 |
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Second Decision |
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2015-11-02 16:32 |
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Accepted by Journal Editor-in-Chief |
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2015-11-02 19:56 |
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Accepted by Executive Editor-in-Chief |
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2015-11-19 13:28 |
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Articles in Press |
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2015-11-19 13:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-10 16:56 |
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Publish the Manuscript Online |
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2015-12-24 11:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
On deaf ears, Mycobacterium avium paratuberculosis in pathogenesis Crohn’s and other diseases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
William C Davis |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services |
N01-AI-30055 |
| JDIP program USDA-CSREES-NRI-CAP Award |
2007-01019(to Davis WC) |
| USDA-NRI grant |
2005-35204-16106 |
| Washington State University Monoclonal Antibody Center |
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| Corresponding Author |
William C Davis, PhD, Professor, Department Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-7040, United States. davisw@vetmed.wsu.edu
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| Key Words |
Crohn’s disease; Johne’s disease; Mycobacterium avium subsp. paratuberculosis; Animal model; Monoclonal antibodies; Flow cytometry; Cytokines |
| Core Tip |
The seminal finding from recent investigations is the detection of Mycobacterium avium subsp. paratuberculosis (Map) in healthy individuals with no clinical signs of disease. The latter observation indicates all humans are susceptible to infection with Mycobacterium avium subsp. paratuberculosis (Map) and lends support to the thesis that Map is zoonotic, with a latent stage of infection similar to M. tuberculosis, where infection leads to the development of an immune response that controls but does not eliminate the pathogen. This clarifies one of the reasons why it has been so difficult to document that Map is zoonotic and associated with the pathogenesis of Crohn’s disease and other diseases.
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| Publish Date |
2015-12-24 11:11 |
| Citation |
Davis WC. On deaf ears, Mycobacterium avium paratuberculosis in pathogenesis Crohn’s and other diseases. World J Gastroenterol 2015; 21(48): 13411-13417 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i48/13411.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i48.13411 |
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