Publication Name	World Journal of Gastroenterology
Manuscript ID	22102
Country	China

Received	2015-08-12 13:52
Peer-Review Started	2015-08-13 08:26
To Make the First Decision	2015-09-11 09:22
Return for Revision	2015-09-15 10:37
Revised	2015-09-18 11:31
Second Decision	2015-09-28 16:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:05
Articles in Press	2015-09-30 10:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-27 14:11
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Amy P Chiu, Barbara R Tschida, Lilian H Lo, Branden S Moriarity, Dewi K Rowlands, David A Largaespada and Vincent W Keng
Funding Agency and Grant Number	Funding Agency Grant Number Health Medical Research Fund 11122171 Food and Health Bureau Hong Kong SAR Government Department of Applied Biology and Chemical Technology Hong Kong Polytechnic University Hong Kong SAR 1-ZVAG Hong Kong SAR G-YBAY Hong Kong SAR G-UA94 Hong Kong SAR 1-ZE19 NIH IMVTP grant T32 AI083196-04（ to Tschida BR）
Corresponding Author	Vincent W Keng, PhD, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. vincent.keng@polyu.edu.hk
Key Words	Hepatocellular carcinoma; Hepatitis B virus; Transposable elements; Sleeping Beauty; Forward and reverse genetic screens
Core Tip	Hepatocellular carcinoma (HCC) is the major type of primary liver cancer and the risk factors that contribute to its formation are hepatitis viral infection, alcohol consumption, aflatoxin exposure, hemochromatosis, and tyrosinemia. In vivo forward and reverse genetic transposon models have been used to study the genetic mechanisms of HCC, including hepatitis B viral-induced HCC. These animal models provide valuable genetic information and are important contributors to uncovering the factors involved in liver malignant transformation, invasion and metastasis. They could also be used to test potential therapeutic agents before proceeding to clinical trials in humans.
Publish Date	2015-11-11 13:34
Citation	Chiu AP, Tschida BR, Lo LH, Moriarity BS, Rowlands DK, Largaespada DA, Keng VW. Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma. World J Gastroenterol 2015; 21(42): 12157-12170
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12157.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12157

Full Article (PDF)	WJG-21-12157.pdf
Full Article (Word)	WJG-21-12157.doc
Manuscript File	22102-Review.docx
Answering Reviewers	22102-Answering reviewers.pdf
Audio Core Tip	22102-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22102-Conflict-of-interest statement.pdf
Copyright License Agreement	22102-Copyright assignment.pdf
Peer-review Report	22102-Peer-review(s).pdf
Scientific Misconduct Check	22102-Scientific misconduct check.pdf
Scientific Editor Work List	22102-Scientific editor work list.pdf