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Publication Name World Journal of Gastroenterology
Manuscript ID 22141
Country/Territory United States
Received
2015-08-16 14:01
Peer-Review Started
2015-08-18 10:08
To Make the First Decision
2015-09-29 13:50
Return for Revision
2015-10-16 11:29
Revised
2015-10-27 06:40
Second Decision
2015-11-02 16:32
Accepted by Journal Editor-in-Chief
2015-11-04 09:32
Accepted by Company Editor-in-Chief
2015-11-19 13:29
Articles in Press
2015-11-19 13:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-28 19:10
Publish the Manuscript Online
2016-03-02 13:35
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus
Manuscript Source Unsolicited Manuscript
All Author List Neal Patel, Kian Bichoupan, Lawrence Ku, Rachana Yalamanchili, Alyson Harty, Donald Gardenier, Michel Ng, David Motamed, Viktoriya Khaitova, Nancy Bach, Charissa Chang, Priya Grewal, Meena Bansal, Ritu Agarwal, Lawrence Liu, Gene Im, Jennifer Leong, Leona Kim-Schluger, Joseph Odin, Jawad Ahmad, Scott Friedman, Douglas Dieterich, Thomas Schiano, Ponni Perumalswami and Andrea Branch
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health DA031095
National Institutes of Health DK090317
Corresponding author Andrea Branch, PhD, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Icahn Medical Institute, 11th floor, Room 24, 1425 Madison Avenue, New York, NY 10029, United States. andrea.branch@mssm.edu
Keywords Hepatitis C virus; Sofosbuvir; Ribavirin; Anemia; Hepatic decompensation; Serious adverse event; Liver transplant
Core Tip Direct acting antivirals have changed the landscape of managing hepatitis C virus (HCV) infection, but there is limited data on the full safety profile of these drugs. We studied a group of liver transplant recipients with recurrent HCV who had hepatic decompensation and/or serious adverse events while on treatment with sofosbuvir-based regimens. We found that cases had lower pre-treatment hemoglobin, estimated glomerular filtration rate, and higher pre-treatment serum total bilirubin levels compared to controls. Anemia was the most common event and 62% of cases required blood transfusion. Similar to registration trials, sofosbuvir was generally well-tolerated, while ribavirin-induced anemia remains a challenge.
Publish Date 2016-03-02 13:35
Citation Patel N, Bichoupan K, Ku L, Yalamanchili R, Harty A, Gardenier D, Ng M, Motamed D, Khaitova V, Bach N, Chang C, Grewal P, Bansal M, Agarwal R, Liu L, Im G, Leong J, Kim-Schluger L, Odin J, Ahmad J, Friedman S, Dieterich D, Schiano T, Perumalswami P, Branch A. Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus. World J Gastroenterol 2016; 22(9): 2844-2854
Url http://www.wjgnet.com/1007-9327/full/v22/i9/2844.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i9.2844
Full Article (PDF) WJG-22-2844.pdf
Full Article (Word) WJG-22-2844.doc
Manuscript File 22141-Review.docx
Answering Reviewers 22141-Answering reviewers.pdf
Audio Core Tip 22141-Audio core tip.mp3
Biostatistics Review Certificate 22141-Biostatistics statment.pdf
Conflict-of-Interest Disclosure Form 22141-Conflict-of-interest statement.pdf
Copyright License Agreement 22141-Copyright assignment.pdf
Data Sharing Statement 22141-Data sharing statment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150815011030.docx
Institutional Review Board Approval Form or Document 22141-Institutional review board statement.pdf
Peer-review Report 22141-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 22141-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 22141-Scientific misconduct check.pdf
Scientific Editor Work List 22141-Scientific editor work list.pdf