Publication Name	World Journal of Stem Cells
Manuscript ID	22166
Country	Japan

Received	2015-08-17 14:34
Peer-Review Started	2015-08-21 11:47
To Make the First Decision	2015-09-28 11:55
Return for Revision	2015-09-30 15:08
Revised	2015-10-09 18:24
Second Decision	2015-12-24 17:48
Accepted by Journal Editor-in-Chief	2015-12-24 19:57
Accepted by Executive Editor-in-Chief	2016-01-11 15:35
Articles in Press	2016-01-11 15:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-17 19:26
Publish the Manuscript Online	2016-02-23 14:18

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Human pluripotent stem cells: Towards therapeutic development for the treatment of lifestyle diseases
Manuscript Source	Invited Manuscript
All Author List	Miwako Nishio, Masako Nakahara, Akira Yuo and Kumiko Saeki
Funding Agency and Grant Number
Corresponding Author	Kumiko Saeki, MD, PhD, Director, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. saeki@ri.ncgm.go.jp
Key Words	Arteriostenosis; Human embryonic stem cells; Glucose intolerance; Human induced pluripotent stem cells; Brown adipose tissue
Core Tip	Clinical application of human embryonic stem cells (ESCs)/induced pluripotent stem cells (iPSCs) is currently limited to remediless diseases due to risk of tumorigenesis. However, application of these cells to therapeutic purposes and drug discovery for lifestyle diseases is promising. Because a short-term presence of human ESC/iPSC-derived vascular endothelial cells reportedly exerts long-term therapeutic effects on injured stenotic arteries, immunologically rejections can nullify risk of tumorigenesis without deteriorating therapeutic effects. Another utility is to produce high-scarcity-valued cells such as brown adipocytes, which are unobtainable from living bodies and commercially available sources, as a new tool for drug discovery for lifestyle diseases.
Publish Date	2016-02-23 14:18
Citation	Nishio M, Nakahara M, Yuo A, Saeki K. Human pluripotent stem cells: Towards therapeutic development for the treatment of lifestyle diseases. World J Stem Cells 2016; 8(2): 56-61
URL	http://www.wjgnet.com/1948-0210/full/v8/i2/56.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i2.56

Full Article (PDF)	WJSC-8-56.pdf
Full Article (Word)	WJSC-8-56.doc
Manuscript File	22166-Review.docx
Answering Reviewers	22166-Answering reviewers.pdf
Audio Core Tip	22166-Audio core tip.wma
Conflict-of-Interest Disclosure Form	22166-Conflict-of-interest statement.pdf
Copyright License Agreement	22166-Copyright assignment.pdf
Peer-review Report	22166-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22166-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22166-Scientific misconduct check.pdf
Scientific Editor Work List	22166-Scientific editor work list.pdf