Publication Name	World Journal of Surgical Procedures
Manuscript ID	22257
Country	United States

Received	2015-08-22 18:02
Peer-Review Started	2015-08-23 16:07
To Make the First Decision	2015-10-27 10:43
Return for Revision	2015-10-28 13:37
Revised	2015-12-12 23:45
Second Decision	2015-12-29 11:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-07 16:53
Articles in Press	2016-01-07 16:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-10 15:14
Publish the Manuscript Online	2016-03-25 15:16

ISSN	2219-2832 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Minireviews
Article Title	Should multi-gene panel testing replace limited BRCA1/2 testing? A review of genetic testing for hereditary breast and ovarian cancers
Manuscript Source	Invited Manuscript
All Author List	Nimmi S Kapoor and Kimberly C Banks
Funding Agency and Grant Number
Corresponding Author	Nimmi S Kapoor, MD, Director, Department of Surgical Oncology, Breastlink, 230 S. Main Street, Suite 100, Orange, CA 92868, United States. nimmi.kapoor@breastlink.com
Key Words	Panel testing; Genetic testing; BRCA; Breast cancer
Core Tip	Evaluating multiple genes in a panel test has clear advantages over BRCA1/2 testing including a greater likelihood of identifying patients with actionable pathogenic mutations, improved efficiency over sequential testing, and lower overall cost. At the same time, panel testing comes with limitations; most notably a lack of clear management guidelines for mutations in moderate penetrance genes and limited evidence-based clinical validity. As more information is gathered on these moderate- and low-penetrance gene mutations, the ability to guide clinical decisions for patients will continue to improve.
Publish Date	2016-03-25 15:16
Citation	Kapoor NS, Banks KC. Should multi-gene panel testing replace limited BRCA1/2 testing? A review of genetic testing for hereditary breast and ovarian cancers. World J Surg Proced 2016; 6(1): 13-18
URL	http://www.wjgnet.com/2219-2832/full/v6/i1/13.htm
DOI	http://dx.doi.org/10.5412/wjsp.v6.i1.13

Full Article (PDF)	WJSP-6-13.pdf
Full Article (Word)	WJSP-6-13.doc
Manuscript File	22257-Review.docx
Answering Reviewers	22257-Answering reviewers.pdf
Audio Core Tip	22257-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22257-Conflict-of-interest statement.pdf
Copyright License Agreement	22257-Copyright assignment.pdf
Peer-review Report	22257-Peer-review(s).pdf
Scientific Misconduct Check	22257-Scientific misconduct check.pdf
Scientific Editor Work List	22257-Scientific editor work list.pdf