Publication Name	World Journal of Nephrology
Manuscript ID	22286
Country	Japan

Received	2015-08-31 08:46
Peer-Review Started	2015-08-31 10:55
To Make the First Decision	2015-10-27 10:43
Return for Revision	2015-10-28 13:39
Revised	2015-11-17 12:54
Second Decision	2015-12-07 09:31
Accepted by Journal Editor-in-Chief	2015-12-10 18:01
Accepted by Company Editor-in-Chief	2015-12-14 17:50
Articles in Press	2015-12-14 17:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-04 16:03
Publish the Manuscript Online	2016-01-06 20:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Central blood pressure and chronic kidney disease
Manuscript Source	Invited Manuscript
All Author List	Yoichi Ohno, Yoshihiko Kanno and Tsuneo Takenaka
Funding Agency and Grant Number
Corresponding Author	Tsuneo Takenaka, MD, PhD, Department of Medicine, International University of Health and Welfare, Clinical Research Center, Sanno Hospital, 8-10-16 Akasaka Minato, Tokyo 107-0052, Japan. takenaka@iuhw.ac.jp
Key Words	Atherosclerosis; Mineral and bone disorder; Oxidative stress; Proteinuria; Renal autoregulation
Core Tip	Wave reflection is a major mechanism that determines central blood pressure in chronic kidney disease (CKD). Diminished renal autoregulatory ability characterizes CKD, allowing an increase in proteinuria. Thus, any elevations of central blood pressure accelerate the progression of CKD. The kidney produces oxidative stress compounds due to proteinuria handling and secondary interstitial inflammation. Oxidative stress facilitates atherogenesis, increases arterial stiffness and central blood pressure. Furthermore, even in early stages of CKD, mineral and bone disorder (MBD) is developed. CKD-MBD facilitates to induce oxidative stress and elevation of central blood pressure. To keep vascular health in CKD, early intervention or prevention seems mandatory.
Publish Date	2016-01-06 20:46
Citation	Ohno Y, Kanno Y, Takenaka T. Central blood pressure and chronic kidney disease. World J Nephrol 2016; 5(1): 90-100
URL	http://www.wjgnet.com/2220-6124/full/v5/i1/90.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i1.90

Full Article (PDF)	WJN-5-90.pdf
Full Article (Word)	WJN-5-90.doc
Manuscript File	22286-Review.docx
Answering Reviewers	22286-Answering reviewers.pdf
Audio Core Tip	22286-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22286-Conflict-of-interest statement.pdf
Copyright License Agreement	22286-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22286-Language certificate.pdf
Peer-review Report	22286-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22286-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22286-Scientific misconduct check.pdf
Scientific Editor Work List	22286-Scientific editor work list.pdf