Publication Name	World Journal of Transplantation
Manuscript ID	22291
Country	Israel

Received	2015-08-24 17:11
Peer-Review Started	2015-08-27 17:07
First Decision by Editorial Office Director
Return for Revision	2015-10-09 10:33
Revised	2015-11-02 04:04
Publication Fee Transferred
Second Decision by Editor	2015-12-10 17:53
Second Decision by Editor-in-Chief	2015-12-12 00:19
Final Decision by Editorial Office Director	2015-12-20 15:54
Articles in Press	2015-12-20 15:54
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-03 16:39
Publish the Manuscript Online	2016-03-18 14:28

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Review
Article Title	Survival of encapsulated islets: More than a membrane story
Manuscript Source	Invited Manuscript
All Author List	Uriel Barkai, Avi Rotem and Paul de Vos
Funding Agency and Grant Number
Corresponding Author	Uriel Barkai, PhD, Beta-O2 Technologies, 11 Amal St, POB 11793, Rosh HaAyin 4809900, Israel. u.barkai@beta-o2.com
Key Words	Bio-artificial pancreas; Diabetes; Islets of Langerhans; Encapsulation; Oxygen supply; Permselective membrane; Transplantation
Core Tip	Replacing standard insulin therapy for patients with type Ⅰ diabetics with a cell-based cure is yet to be achieved. Assuming unlimited supply of beta cells, allogeneic or xenogeneic cells should be separated from the host immune system by a permselective membrane that still allows insulin egress. In addition, a mandatory requirement for such a cure in a poorly oxygenated environment includes adequate oxygen supply. In addition, to optimize islet functionality, control over inflammation, cell apoptosis, angiogenesis, and the close environment of the transplanted cells must be accomplished.
Publish Date	2016-03-18 14:28
Citation	Barkai U, Rotem A, de Vos P. Survival of encapsulated islets: More than a membrane story. World J Transplant 2016; 6(1): 69-90
URL	http://www.wjgnet.com/2220-3230/full/v6/i1/69.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i1.69

Full Article (PDF)	WJT-6-69.pdf
Full Article (Word)	WJT-6-69.doc
Manuscript File	22291-Review.docx
Answering Reviewers	22291-Answering reviewers.pdf
Audio Core Tip	22291-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22291-Conflict-of-interest statement.pdf
Copyright License Agreement	22291-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22291-Language certificate.pdf
Peer-review Report	22291-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22291-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22291-Scientific misconduct check.pdf
Scientific Editor Work List	22291-Scientific editor work list.pdf