Publication Name	World Journal of Experimental Medicine
Manuscript ID	22384
Country	Germany

Received	2015-08-28 09:52
Peer-Review Started	2015-08-31 17:13
To Make the First Decision	2015-10-27 11:22
Return for Revision	2015-11-04 20:56
Revised	2015-11-13 20:29
Second Decision	2016-02-22 11:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-03-18 16:27
Articles in Press	2016-03-18 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-26 17:53
Publish the Manuscript Online	2016-05-17 10:07

ISSN	2220-315x (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	MicroRNA-regulated viral vectors for gene therapy
Manuscript Source	Invited Manuscript
All Author List	Anja Geisler and Henry Fechner
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft FE785/2-2 Deutsche Forschungsgemeinschaft FE785/4-1 Bundesministerium für Bildung und Entwicklung 031A331
Corresponding Author	Henry Fechner, DVM, Department of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355 Berlin, Germany. henry.fechner@tu-berlin.de
Key Words	MicroRNA; MicroRNA regulation; MicroRNA target sites; Viral vectors; Adeno-associated virus; RNA interference; Gene therapy; Vector targeting
Core Tip	Post-transcriptional microRNA-induced suppres-sion of gene expression is a simple new, highly efficient technology to restrict transgene expression to a specific tissue. It is based on the insertion of a target sequence for a cell-specifically expressed microRNA, typically into the 3’ untranslated region of a transgene expression cassette. MicroRNA-induced regulation can result in an up to 100-fold reduction of transgene expression in tissues where expression is not desired. This targeting strategy can be used in combination with other targeting strategies to further improve vector specificity for gene therapeutic approaches.
Publish Date	2016-05-17 10:07
Citation	Geisler A, Fechner H. MicroRNA-regulated viral vectors for gene therapy. World J Exp Med 2016; 6(2): 37-54
URL	http://www.wjgnet.com/2220-315X/full/v6/i2/37.htm
DOI	http://dx.doi.org/10.5493/wjem.v6.i2.37

Full Article (PDF)	WJEM-6-37.pdf
Full Article (Word)	WJEM-6-37.doc
Manuscript File	22384-Review.doc
Answering Reviewers	22384-Answering reviewers.pdf
Audio Core Tip	22384-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22384-Conflict-of-interest statement.pdf
Copyright License Agreement	22384-Copyright assigment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22384-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	22384-Language certificate.pdf
Peer-review Report	22384-Peer-review(s).pdf
Scientific Misconduct Check	22384-Scientific misconduct check.pdf
Scientific Editor Work List	22384-Scientific editor work list.pdf