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Articles Published Processes
3/21/2016 8:21:00 AM | Browse: 1296 | Download: 2634
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Received |
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2015-09-12 16:39 |
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Peer-Review Started |
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2015-09-16 15:42 |
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To Make the First Decision |
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2015-10-27 11:05 |
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Return for Revision |
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2015-11-07 15:51 |
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Revised |
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2015-11-27 04:28 |
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Second Decision |
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2016-02-15 17:14 |
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Accepted by Journal Editor-in-Chief |
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2016-02-16 11:59 |
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Accepted by Executive Editor-in-Chief |
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2016-02-24 14:25 |
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Articles in Press |
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2016-02-24 14:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-02 10:34 |
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Publish the Manuscript Online |
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2016-03-21 08:20 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hanaa H Ahmed, Ahmed M Salem, Hazem M Atta, Emad F Eskandar, Abdel Razik H Farrag, Mohamed A Ghazy, Neveen A Salem and Hadeer A Aglan |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hanaa H Ahmed, PhD, Professor of Biochemistry, Hormones Department, Medical Research Division, National Research Centre, 33 El-Bohouth Street, Dokki, Giza 12622, Egypt. hanaaomr@yahoo.com |
| Key Words |
Parkinson’s disease; Pathophysiology; Bone marrow derived mesenchymal stem cells; Rotenone; Anti-inflammatory action; Ovariectomy; Anti-apoptotic effect; Neurogenic potential |
| Core Tip |
The current study was planned to clarify the mode of action of mesenchymal stem cells (MSCs) in targeting multiple systems implicated in the pathophysiology of Parkinson’s disease (PD) in the rat model. For this purpose, the MSCs were isolated from bone marrow (BM) of rat femur bone and PD was induced in ovariectomized rats by rotenone administration for 14 d. Our results provided clear evidences for the therapeutic role of BM-derived MSCs against PD pathophysiology through their immunomodulatory properties, anti-inflammatory and anti-apoptotic effects as well as neurotrophic and neurogenic potentials. |
| Publish Date |
2016-03-21 08:20 |
| Citation |
Ahmed HH, Salem AM, Atta HM, Eskandar EF, Farrag ARH, Ghazy MA, Salem NA, Aglan HA. Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells. World J Stem Cells 2016; 8(3): 106-117 |
| URL |
http://www.wjgnet.com/1948-0210/full/v8/i3/106.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v8.i3.106 |
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