Publication Name	World Journal of Gastroenterology
Manuscript ID	22446
Country	China

Received	2015-08-29 16:59
Peer-Review Started	2015-09-01 09:52
To Make the First Decision	2015-09-29 12:43
Return for Revision	2015-10-08 17:29
Revised	2015-11-02 21:28
Second Decision	2016-01-06 11:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-18 10:21
Articles in Press	2016-01-18 10:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-03-02 09:19
Typeset the Manuscript	2016-03-15 10:45
Publish the Manuscript Online	2016-03-29 15:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Evaluation of therapeutic effectiveness of 131I-antiEGFR-BSA-PCL in a mouse model of colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Li, Yan-Hui Ji, Cheng-Xia Li, Zhong-Yun Liu, Ning Li, Lei Fang, Jin Chang and Jian Tan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81301244 (to Li W) National Key Clinical Specialty Project
Corresponding Author	Jian Tan, MD, Professor of Medicine, Chief, Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin 300052, China. tanpost@163.com
Key Words	Radioiodine therapy; Colorectal cancer; Liposome; Epidermal growth factor receptor; Mouse
Core Tip	This paper describes liposomes that were assessed for EGFR-targeted binding and cellular uptake in EGFR-overexpressing LS180 colorectal cancer cells and a mouse model of colorectal cancer. Anti-EGFR and non-targeted liposomes were labeled with 131I using the chloramine-T method. The time-dependent cellular uptake of 131I-antiEGFR-BSA-PCL and 131I-BSA-PCL demonstrated the slow-release effects of nanoparticles. The results of confocal microscopic analysis revealed the significant uptake of antiEGFR-BSA-PCL in LS180 cells. This study also investigated the biological effects of internal irradiation and the therapeutic efficacy of 131I-antiEGFR-BSA-PCL on colorectal cancer in a BALB/c mouse model. To address this issue, tumor size, body weight, histopathology, and SPECT imaging were monitored for 33 d post-therapy. The 131I-antiEGFR-BSA-PCL was demonstrated to be superior in regard to cellular binding and uptake compared with control BSA-PCL in the mouse model.
Publish Date	2016-03-29 15:29
Citation	Li W, Ji YH, Li CX, Liu ZY, Li N, Fang L, Chang J, Tan J. Evaluation of therapeutic effectiveness of 131I-antiEGFR-BSA-PCL in a mouse model of colorectal cancer. World J Gastroenterol 2016; 22(14): 3758-3768
URL	http://www.wjgnet.com/1007-9327/full/v22/i14/3758.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i14.3758

Full Article (PDF)	WJG-22-3758.pdf
Full Article (Word)	WJG-22-3758.doc
Manuscript File	22446-Review .doc
Answering Reviewers	22446-Answering reviewers.pdf
Audio Core Tip	22446-Audio core tip.mp3
Biostatistics Review Certificate	22446-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	22446-Conflict-of-interest statement.pdf
Copyright License Agreement	22446-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22446-Grant application form.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150828221007.docx
Institutional Animal Care and Use Committee Approval Form or Document	22446-Institutional animal care and use committee statement.pdf
Supplementary Material	Supplementary_Material_20150828221040.docx
Peer-review Report	22446-Peer-review(s).pdf
Scientific Misconduct Check	22446-Scientific misconduct check.pdf
Scientific Editor Work List	22446-Scientific editor work list.pdf