Publication Name	World Journal of Neurology
Manuscript ID	22479
Country	United States

Received	2015-09-26 14:34
Peer-Review Started	2015-10-06 01:27
To Make the First Decision	2015-11-24 14:41
Return for Revision	2015-11-27 08:25
Revised	2015-12-25 03:54
Second Decision	2016-01-04 14:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-19 10:14
Articles in Press	2016-01-19 10:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-10 14:58
Publish the Manuscript Online	2016-03-25 15:11

ISSN	2218-6212 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Aquaporin-4 and spinal cord injury
Manuscript Source	Invited Manuscript
All Author List	Jennifer M Yonan and Devin K Binder
Funding Agency and Grant Number
Corresponding Author	Devin K Binder, MD, PhD, Division of Biomedical Sciences, School of Medicine, Center for Glial-Neuronal Interactions, Neuroscience Graduate Program, University of California at Riverside, 1247 Webber Hall, Riverside, CA 92521, United States. dbinder@ucr.edu
Key Words	Spinal cord injury; Astrocyte; Aquaporin-4; Edema; Water channel
Core Tip	Edema formation is a major problem following spinal cord injury (SCI) that acts to exacerbate secondary damage. Animal models have become an integral part of understanding this pathophysiology. Several SCI models have been developed, resulting in difficult interpretation between studies with conflicting results. This is true for the role of aquaporin-4 (AQP4) water channels in the development and resolution of edema following SCI. Here, we discuss regulation of AQP4 in varying models and the effect of current interventions on expression, edema formation and functional recovery. Understanding the precise role of AQP4 will help to determine optimal treatments following human SCI.
Publish Date	2016-03-25 15:11
Citation	Yonan JM, Binder DK. Aquaporin-4 and spinal cord injury. World J Neurol 2016; 6(1): 1-13
URL	http://www.wjgnet.com/2218-6212/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.5316/wjn.v6.i1.1

Full Article (PDF)	WJN-6-1.pdf
Full Article (Word)	WJN-6-1.doc
Manuscript File	22479-Review.docx
Answering Reviewers	22479-Answering reviewers.pdf
Audio Core Tip	22479-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22479-Conflict-of-interest statement.pdf
Copyright License Agreement	22479-Copyright assignment.pdf
Peer-review Report	22479-Peer-review(s).pdf
Scientific Misconduct Check	22479-Scientific misconduct check.pdf
Scientific Editor Work List	22479-Scientific editor work list.pdf